In biology, the active site is region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form temporary bonds with the substrate (binding site) and residues that catalyse a reaction of that substrate (catalytic site). Although the active site occupies only ~10–20% of the volume of an enzyme, it is the most important part as it directly catalyzes the chemical reaction. It usually consists of three to four amino acids, while other amino acids within the protein are required to maintain the tertiary structure of the enzymes.

Hadi Soesastro (Born Tan Yueh Ming April 30, 1945 – May 4, 2010, widely known as Hadi or "Mingkie") was an Indonesian economist, academic and public intellectual. Hadi was one of the founders of the Centre for Strategic and International Studies (CSIS), a think tank founded in 1971, where he served as an executive director and economist. The Jakarta Post referred to Soesastro as "one of Indonesia’s foremost economists." Soesastro was born in the city of Malang, East Java, Indonesia. Soesastro graduated with an aeronautical engineering degree from the Technische Hochschule in Aachen, Germany. Aside from his studies, Hadi was active in the Indonesian students association, becoming chairman of the West German branch. Soesastro obtained his doctorate from the Frederick S. Pardee RAND Graduate School in Santa Monica, California. He worked as an economist at the CSIS, which he helped to found. He worked as an advisor to both the World Bank and the Asian Development Bank. From December 1999 until September 2000, Soesastro served as an economic advisor to Indonesian President Abdurrahman Wahid as a member of the president's National Economic Council. Within the academic field, Soesastro was an adjunct professor at Columbia University in New York City. and Australian National University's Research School of Pacific and Asian Studies (RSPAS) and maintained close links with the activities of the Indonesia project in the RSPAS. The Hadi Soesastro Prize honours one of Indonesia’s most eminent thinkers, the late Professor Hadi Soesastro, who was a great friend of Australia. Professor Soesastro was an economist, academic and public intellectual who made major contributions to Asia-Pacific cooperation. Soesastro was board member of the Asia Society in New York and founding member of the Pacific Economic Council Cooperation

In biology, the active site is region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form temporary bonds with the substrate (binding site) and residues that catalyse a reaction of that substrate (catalytic site). Although the active site occupies only ~10–20% of the volume of an enzyme, it is the most important part as it directly catalyzes the chemical reaction. It usually consists of three to four amino acids, while other amino acids within the protein are required to maintain the tertiary structure of the enzymes. Each active site is evolved to be optimised to bind a particular substrate and catalyse a particular reaction, resulting in high specificity. This specificity is determined by the arrangement of amino acids within the active site and the structure of the substrates. Sometimes enzymes also need to bind with some cofactors to fulfil their function. The active site is usually a groove or pocket of the enzyme which can be located in a deep tunnel within the enzyme, or between the interfaces of multimeric enzymes. An active site can catalyse a reaction repeatedly as residues are not altered at the end of the reaction (they may change during the reaction, but are regenerated by the end). This process is achieved by lowering the activation energy of the reaction, so more substrates have enough energy to undergo reaction.