The 2021 Kansas Jayhawks football team will represent the University of Kansas in the . It will be the Jayhawks 132nd season. The Jayhawks will be led by second-year head coach Les Miles. They are members of the Big 12 Conference. They will play their home games at David Booth Kansas Memorial Stadium. The Jayhawks will look to rebound from their 3rd winless season in program history after finishing 0–9 in the 2020 season, which was shortened due to the COVID-19 pandemic. The Jayhawks will look to end multiple streaks during the season, 41 games to AP ranked teams, 54 road conference games, and an overall losing streak of 13. They will also look to qualify for a bowl game for the first time since the 2008 season.