Mitooma District

Jōban Line and Mito Line

Mitogen-activated protein kinase kinase kinase

Q8NE86

Mitoguazone

Mitosis-promoting factor

Mitogen-activated protein kinase 10

Satomi Kōtarō on set in the role of Mitsuemon

Phalangium urnigerum

Mayor

Mito school

Mitochondrial disorders

Municipality

Mitochondrial macro-haplogroups L0, L1, and L5

Mitoizumi Masayuki

Mito Tōshō-gū

Mitopiella cinctipes

Mitotane

Mitoizumi Masayuki (born 2 September 1962 as Masato Koizumi) is a former sumo wrestler from Mito, Ibaraki, Japan. His professional career spanned 22 years, from 1978 until 2000. The highest rank he reached was sekiwake. He won over 800 career bouts and took the yūshō or championship in the top makuuchi division in 1992. Mitoizumi was nicknamed the "Salt Shaker", due to his habit of throwing enormous quantities of purifying salt onto the ring (dohyō) during the pre-match preliminaries.

Mitosis promoting factor

Opilio cinerascens

Mitochondrial ROS (mtROS or mROS) are reactive oxygen species (ROS) that are produced by mitochondria. Generation of mitochondrial ROS mainly takes place at the electron transport chain located on the inner mitochondrial membrane during the process of oxidative phosphorylation (OXPHOS). Leakage of electrons at complex I and complex III from electron transport chains leads to partial reduction of oxygen to form superoxide. Subsequently, superoxide is quickly dismutated to hydrogen peroxide by two dismutases including superoxide dismutase 2 (SOD2) in mitochondrial matrix and superoxide dismutase 1 (SOD1) in mitochondrial intermembrane space. Collectively, both superoxide and hydrogen peroxide generated in this process are considered as mitochondrial ROS.Once thought as merely the by-products of cellular metabolism, mitochondrial ROS are increasingly viewed as important signaling molecules. At low levels, mitochondrial ROS are considered to be important for metabolic adaptation as seen in hypoxia. Mitochondrial ROS, stimulated by danger signals such as lysophosphatidylcholine and Toll-like receptor 4 and Toll-like receptor 2 bacterial ligands lipopolysaccharide (LPS) and lipopeptides, are involved in macrophage bactericidal activity. Finally, high levels of mitochondrial ROS activate apoptosis/autophagy pathways capable of inducing cell death.

Mitochondrial toxicity is a condition in which the mitochondria of a body's cells become damaged or decline significantly in number; it occurs as a side effect of certain antiretroviral drugs used to treat human immunodeficiency virus, or HIV.

Mito Kōmon

Mitochondrial ROS (mtROS or mROS) are reactive oxygen species (ROS) that are produced by mitochondria. Generation of mitochondrial ROS mainly takes place at the electron transport chain located on the inner mitochondrial membrane during the process of oxidative phosphorylation (OXPHOS). Leakage of electrons at complex I and complex III from electron transport chains leads to partial reduction of oxygen to form superoxide.

The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria.

Mitotan

Mitochondrial inheritance

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is a rare autosomal recessive mitochondrial disease. It has been previously referred to as polyneuropathy, ophthalmoplegia, leukoencephalopathy, and POLIP syndrome. The disease presents in childhood, but often goes unnoticed for decades. Unlike typical mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations, MNGIE is caused by mutations in the TYMP gene, which encodes the enzyme thymidine phosphorylase. Mutations in this gene result in impaired mitochondrial function, leading to intestinal symptoms as well as neuro-ophthalmologic abnormalities. A secondary form of MNGIE, called MNGIE without leukoencephalopathy, can be caused by mutations in the POLG gene.

Mitochondrial membrane transporter

Mito Station

Rob DeSalle

Religions

Ōarai-Kashima Line

Animalia

L01

M. morio

Mitos Yggdrasill

Mitochondrial peripheral space

Arachnida

Thorell, 1876

Mitokōmon

Mitochondrial eve

CC1=CN

Mitopus montanus

Kashima Rinkai Tetsudo Ōarai-Kashima Line

Mitogenome

bottom

Phalangium morio

Mitosan

C10orf42, CCDC109A, FLJ46135

Mitopus californicus

Mitochondrial dna

Mitooma District is a district in Western Uganda. It is named after its main municipal, administrative and commercial center, Mitooma.

Mitochondrial inner membrane

Ma. Milagros "Mitos" Habana-Magsaysay (born January 4, 1964), is a Filipino politician who served as Congresswoman of the 1st district of Zambales from 2004 to 2013, and was a senatorial candidate of the United Nationalist Alliance in the 2013 elections.

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. This process was first mentioned by J.J. Lemasters in 2005, although lysosomes in the liver that contained mitochondrial fragments had been seen as early as 1962, “As part of almost every lysosome in these glucagon-treated cells it is possible to recognize a mitochondrion or a remnant of one.

Mitochondrial amidoxime reducing component 1 is a protein that in humans is encoded by the MARC1 gene.

Mitoguazone (also known as methylglyoxal bis(guanylhydrazone) or MGBG) is a drug used in chemotherapy.

Mitospore

Mitochondrial myopathy-encephalopathy-lactic acidosis-stroke syndrome

XX23

Mitochondrial intermediate cleaving peptidase 55 kDa

Municipality of Mitontic in Chiapas

The Mitocu River near its outflow into the Suceava River

Mitothrips

Mito komon

The Mitochondrial Apoptosis-Induced Channel (or MAC), is an early marker of the onset of apoptosis. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli. MAC activity is detected by patch clamping mitochondria from apoptotic cells at the time of cytochrome c release.Members of the Bcl-2 protein family regulate apoptosis by controlling the formation of MAC: the pro-apoptotic members Bax and/or Bak form MAC, whereas the anti-apoptotic members like Bcl-2 or Bcl-xL prevent MAC formation. Once formed, MAC mediates the release of cytochrome c to the cytosol, triggering the commitment step of the mitochondrial apoptotic cascade. Depletion of MAC activity is accomplished pharmacologically by specific compounds, namely Bax Channel Inhibitors and MAC inhibitors. Either by knocking down MAC’s main components or by its pharmacological inhibition, the end result is prevention of cytochrome c release and apoptosis.

inline,title

Mitofsky International

Mitontic

Mitocu River

Mitochondrial ATPase

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes

Mitochondrial intermediate peptidase

Mitopus

Osaka Line

Mitochondrial membrane transport proteins are proteins which exist in the membranes of mitochondria and which serve to transport molecules and other factors such as ions into or out of the organelles.

September, 2000

Mitoc, Orhei

Mitochondrial Eve in popular culture

Mitogen-activated protein kinase 8

Mitoc (disambiguation)

POM

Mitomycin-C

Insecta

c. 100–230 kya

Mitogaku (水戸学) refers to a school of Japanese historical and Shinto studies that arose in the Mito Domain (modern-day Ibaraki Prefecture).The school had its genesis in 1657 when Tokugawa Mitsukuni (1628-1700), second head of the Mito Domain, commissioned the compilation of the Dai Nihonshi. Among scholars gathered for the project were Asaka Tanpaku (1656-1737), Sassa Munekiyo (1640-1698), Kuriyama Senpō (1671-1706), and Miyake Kanran (1673-1718).

Species

Mitogen-activated protein kinase kinase kinase 5

Mitogen-activated protein kinase 11

Ethnicities

Mitogen-activated protein kinase kinases

Mitochondrium

Mitología de las Aguas

Moldova

Opilio canescens

Mitochondrial transcription factor A

East Africa

Parry, 1843

Masato Koizumi

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage.

November 2015

A Mitochondrial encephalomyopathy is a form of encephalomyopathy that is associated with a mitochondrial disease.Examples include MELAS and MERRF. These conditions can sometimes present together.KSS is sometimes included in this category, but it is not included in this category in MeSH.

Mitochondrial ribosomal death-associated protein 3

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.

Opilio albipes

Imperial

Mitochondrial encephalomyopathy

Mitochondrial pyruvate carrier 2 (MPC2) also known as brain protein 44 (BRP44) is a protein that in humans is encoded by the MPC2 gene.

Mitophyllus

DAP3

Mitoji Yabunaka

In molecular biology, the mitochondrial ribosomal death-associated protein 3 family of proteins is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).

In human genetics, the Mitochondrial Eve (also mt-Eve, mt-MRCA) is the matrilineal most recent common ancestor (MRCA) of all currently living humans, i.e., the most recent woman from whom all living humans descend in an unbroken line purely through their mothers, and through the mothers of those mothers, back until all lines converge on one woman.

Opilio crypturum

Mitochondrial Diseases

Mito Municipal Botanical Park

Mitochondrial neurogastrointestinal encephalopathy syndrome

Mitochondrial trifunctional protein (MTP) is a protein attached to the inner mitochondrial membrane which catalyzes three out of the four steps in beta oxidation. MTP is hetero-octamer composed of four alpha and four beta subunits:HADHAHADHBThe three functions are 2-enoyl coenzyme A (CoA) hydratase, long-chain 3-hydroxy acyl-coenzyme A dehydrogenase and long-chain 3-ketoacyl CoA thiolase.

Mitophyllus is a genus of large stag beetles endemic to New Zealand.

Director-General of the Asian and Oceanian Affairs Bureau

Mitocasi

Mitochondrial ribosomal protein L42

Mitopus borealis

Fabricius, 1779

Mitochondrial proteins

Mitooma is a town in the Western Region of Uganda. It is the main municipal, administrative, and commercial center of Mitooma District.

Mitostigma castillonii

Mitopus morio

Mito Mitsukuni

Opilio inermis

Official River Code

XX16

Mitogenesis

Mitochondrial Adam

Mitochondrial intermediate peptidase (EC 3.4.24.59, mitochondrial intermediate precursor-processing proteinase, MIP) is an enzyme. This enzyme catalyses the following chemical reactionRelease of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrionThis enzyme is a homologue of thimet oligopeptidase.

James Gordon Jr.

Mitochondrial DNA depletion syndrome

Banks, 1930

Member of the Philippine House of Representatives from Zambales' 1st District

Phalangium palliatum

Mito domain

Mitomycyna C

Mitochondrial processing peptidase

Arthropoda

Stereo, skeletal formula of mitobronitol -2,3,4,5-tetrol

The Mitong is a river of southwestern mainland Equatorial Guinea. It forms part of the Muni Estuary along with the Congue River, Mandyani River, Mitimele River, Utamboni River and Mven River.

Although commonly depicted as bean-like structures, mitochondria form a highly dynamic network within most cells where they constantly undergo fission and fusion. Mitochondria can divide by prokaryotic binary fission and since they require mitochondrial DNA for their function, fission is coordinated with DNA replication. Some of the proteins that are involved in mitochondrial fission have been identified and some of them are associated with mitochondrial diseases.

Mitogen-activated protein kinase 13

Mitopus is a genus of the harvestman family Phalangiidae with nine described species.

Mito Kakizawa (柿沢未途, Kakizawa Mito, born January 21, 1971) is a Japanese politician and member of the House of Representatives, representing the Tokyo 15th district in the House of Representatives.Kakizawa was born in Brussels while his father Koji Kakizawa was stationed overseas with the Ministry of Finance. He grew up in Tokyo, attending Azabu High School and the University of Tokyo. He worked for NHK in Nagano from 1995 to 1999, during which time he worked on the broadcasting of the 1998 Winter Olympics. He resigned to work on his father's campaign in the 1999 gubernatorial election in Tokyo. Although the elder Kakizawa lost this race, he was elected to the House of Representatives in the 2000 election and the younger Kakizawa subsequently served as his assistant.Kakizawa won a seat in the Tokyo metropolitan assembly in the 2001 election, campaigning to reduce the number of wards in Tokyo to twelve. He was reelected in the 2005 election as a member of the Democratic Party of Japan. In 2008, he was involved in a drunk driving accident and left the metropolitan assembly, spending the next year outside politics.He joined Your Party in 2009 and stood as a candidate for the 15th district in the 2009 general election. He failed to win this seat but picked up a seat in the Tokyo proportional representation block. He won the 15th district seat in the 2012 general election. He left Your Party in August 2013, and later joined the new Yuinotoh party formed under Kenji Eda.

Mitochondrial protein-transporting ATPase

Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is a rare autosomal recessive mitochondrial disease. It has been previously referred to as polyneuropathy, ophthalmoplegia, leukoencephalopathy, and POLIP syndrome. The disease presents in childhood, but often goes unnoticed for decades. Unlike typical mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations, MNGIE is caused by mutations in the TYMP gene, which encodes the enzyme thymidine phosphorylase.

Mitochondrial transplant

Mitoizumi Masato

Mitocași

Mitohormesis

for and

Mitosis

Mitolepis

August 2007

(2-(1E)-1-(Diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine)

Location in Mexico

Mitocheck

Mitoc, Botoşani

Mitoc jud Botosani.png

Mitochondrial DNA is an academic journal that publishes review articles on the current and developing technologies around mitochondrial DNA research and discovery. It is published by Informa Healthcare.

yes

Mitogaku (水戸学) refers to a school of Japanese historical and Shinto studies that arose in the Mito Domain (modern-day Ibaraki Prefecture).The school had its genesis in 1657 when Tokugawa Mitsukuni (1628-1700), second head of the Mito Domain, commissioned the compilation of the Dai Nihonshi. Among scholars gathered for the project were Asaka Tanpaku (1656-1737), Sassa Munekiyo (1640-1698), Kuriyama Senpō (1671-1706), and Miyake Kanran (1673-1718). The fundamental approach of the project was Neo-Confucianist, based on the view that historical development followed moral laws. Tokugawa Mitsukuni believed that Japan, as a nation that had long been under the unified rule of the emperor, was a perfect exemplar of a "nation" as understood in Sinocentric thought. The Dai Nihon-shi thus became a history of Japan as ruled by the emperors and emphasised respect for the imperial court and Shinto deities. In order to record historical facts, the school's historians gathered local historical sources, often compiling their own historical works in the process. Early Mitogaku scholarship was focused on historiography and scholarly work.Around the end of the eighteenth century, Mitogaku came to address contemporary social and political issues, beginning the era of Later Mitogaku. The ninth Mito clan leader, Tokugawa Nariaki (1800-1860), greatly expanded Mitogaku by establishing the Kōdōkan as the clan school. In addition to Confucianist and kokugaku thought, the school also absorbed knowledge from medicine, astronomy and other natural sciences. The Later Mitogaku era lasted until the Bakumatsu period. The school exerted a major influence on the sonnō jōi movement and became one of the driving forces behind the Meiji Restoration. However, it failed to gain the protection of the new government and the Kōdōkan was disbanded and its library largely taken over by the state.The Mito-shi Gakkai of Mito city, Ibaraki prefecture, is undertaking research into the historical and ideological aspects of Mitogaku. Major works of the school include Shintō shūsei, Dai Nihon Jingi Shi, and Jingi Shiryō, and collections and studies of fudoki and studies of the Kogo Shūi.

Mitomi (三富村, Mitomi-mura) was a village located in Higashiyamanashi District, Yamanashi Prefecture, Japan.As of 2003, the village had an estimated population of 1,287 and a population density of 9.54 persons per km². The total area was 134.91 km².On March 22, 2005, Mitomi, along with the town of Makioka (also from Higashiyamanashi District), was merged into the expanded city of Yamanashi.

Mitochondrial respiratory chain

MCU

Mitochondrial processing peptidase is an enzyme complex found in mitochondria which cleaves signal sequences from mitochondrial proteins. In humans this complex is composed of two subunits encoded by the genes PMPCA, and PMPCB. The enzyme is also known as (EC 3.4.24.64, processing enhancing peptidase (for one of two subunits), mitochondrial protein precursor-processing proteinase, matrix peptidase, matrix processing peptidase, matrix processing proteinase, or MPP).

First published 1990

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. This process was first mentioned by J.J. Lemasters in 2005, although lysosomes in the liver that contained mitochondrial fragments had been seen as early as 1962, “As part of almost every lysosome in these glucagon-treated cells it is possible to recognize a mitochondrion or a remnant of one. It was also mentioned in 1977 by scientists studying metamorphosis in silkworms, “...mitochondria develop functional alterations which would activate autophagy." Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIP3-like protein X (NIX). Mitophagy is regulated by PINK1 and parkin protein. The occurrence of mitophagy is not limited to the damaged mitochondria but also involves undamaged ones.

Mitotanum

The Mitocu River or Mitoc River is a left tributary of the Suceava River in Romania. Its main tributary is the Dragomirna which joins the Mitocu River about 100 m. upstream of the latter's confluence with the Suceava River.

Mitogen-activated protein kinase phosphatase

Japan

Mito Station South entrance, May 2012

Mitochondria Eve

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage.Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or LASIK; mitomycin C has also been shown to reduce fibrosis in strabismus surgery. The third is in esophageal and tracheal stenosis where application of mitomycin C onto the mucosa immediately following dilatation will decrease re-stenosis by decreasing the production of fibroblasts and scar tissue.Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'. Potential bis-alkylating heterocylic quinones were synthetised in order to explore their antitumoral activities by bioreductive alkylation. Mitomycin is also used as a chemotherapeutic agent in glaucoma surgery.

Mitochondrial cytochrome b

Jesus Vicente Magsaysay

Mitocin-C

Mitochondrial biogenesis

Mitochondrial Myopathy

Mitochondrial mother

3-1-22, Tomoi,Higashiosaka,Osaka

Mito Station (水戸駅, Mito-eki) is a railway station in Mito, Ibaraki, Japan, operated by East Japan Railway Company (JR East) and Kashima Rinkai Tetsudo.

Mitopiella

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Further experiments will be needed to identify the specific subunit localization. Sequence analysis identified three transcript variants that encode two different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q.

The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins.

Mitochondrial membrane transport protein

entrance for Yamato-Yagi and Nabari

Mitochondrial oxidative phosphorylation

Mitochondrial myopathy–encephalopathy–lactic acidosis–stroke syndrome

NWIBSHFKIJFRCO-WUDYKRTCSA-N

Capital

Lysodren
Clc1ccccc1CCCl

The Mito Municipal Botanical Park (水戸市植物公園, Mito-shi Shokubutsu Kōen) is a botanical garden located at 504 Kobuki, Mito, Ibaraki, Japan. It is open daily except Mondays; an admission fee is charged.The garden contains a terrace, rock garden, lawn, water features, and greenhouses heated from burning waste in the adjoining garbage disposal center.

Mitochondrial disease

Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

Mitosporic fungi

Mito Line

Mitong

H3llBot

Mitochondrial hormesis

Mitoc

See text.

Vice-Minister for Foreign Affairs

Mitoguardin 1 is a protein that in humans is encoded by the MIGA1 gene.

Mitosene

Mitochondrial myopathy-encephalopathy-lactic acidosis

Mitogenetic rays

In enzymology, a mitochondrial protein-transporting ATPase (EC 3.6.3.51) is an enzyme that catalyzes the chemical reactionATP + H2O ⇌ {\displaystyle \rightleftharpoons } ADP + phosphateThus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (mitochondrial protein-importing).

Mitomycin C

green

Mitochondrial carrier family of proteins

Opilio affinis

Mitoplast

Mitochondrial cytochrome c oxidase subunit 1

Mitochondrial Ca2+ uniporter

Mitochondrial rRNA MTase 2

Mitoizumi Masayuki (born 2 September 1962 as Masato Koizumi) is a former sumo wrestler from Mito, Ibaraki, Japan. His professional career spanned 22 years, from 1978 until 2000. The highest rank he reached was sekiwake. He won over 800 career bouts and took the yūshō or championship in the top makuuchi division in 1992. Mitoizumi was nicknamed the "Salt Shaker", due to his habit of throwing enormous quantities of purifying salt onto the ring (dohyō) during the pre-match preliminaries. He is now a coach, and is known as Nishikido-oyakata.

Mitopus scaber

Counties

Mitochondrial Eve hypothesis

1-1-1 Miyamachi,Mito,Ibaraki

Mito Station (弥刀駅, Mito-eki) is a railway station on the Kintetsu Osaka Line in Higashiosaka, Osaka Prefecture, Japan.

Mitochondrial neurogastrointestinal encephalopathy

Mitochondrial cytopathy

Mitochondrial calcium uniporter

A mitoplast is a mitochondrion that has been stripped of its outer membrane leaving the inner membrane intact.

CellBiology/Genetics/Evolution

Mitochondrial DNA depletion syndrome (MDS) refers to a group of autosomal recessive disorders which cause the affected tissues to suffer from a significant drop in mitochondrial DNA. Symptoms may manifest as myopathic, hepatopathic, and/or encephalomyopathic. These syndromes affect tissue found in the muscle, liver, or both the muscle and brain, respectively. The condition is typically fatal in infancy and early childhood, though some have survived to their teenage years with the myopathic variant and some have survived into adulthood with the SUCLA2 encephalimyopathic variant There is currently no curative treatment for any form of MDSs, though some preliminary treatments have shown a reduction in symptoms.

(RS)-1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)-ethyl]-benzene

Mitooma

Opilio alpinus

Mito Tosho-gu

MITOTANE

Mitobronitol

Mitochondrial tRNA-uridine2728 uracil mutase

Local

Opilio fasciatus

Mitobronitol (1,6-dibromo-1,6-dideoxy-D-mannitol) is a brominated analog of mannitol. It is an anticancer drug that is classified as an alkylating agent.

M. cinctipes

Mitologia de las Aguas

Opilio serripes

Mitocaşi

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates.

October 2010

C\C=N/NC=N

Decne. 1844 not Blume 1856

Opilio albescens

Mitogen-activated protein kinases

Mitochrondrion

Mitogaku

Mitomania

Mitochondrial processing peptidase is an enzyme complex found in mitochondria which cleaves signal sequences from mitochondrial proteins. In humans this complex is composed of two subunits encoded by the genes PMPCA, and PMPCB. The enzyme is also known as (EC 3.4.24.64, processing enhancing peptidase (for one of two subunits), mitochondrial protein precursor-processing proteinase, matrix peptidase, matrix processing peptidase, matrix processing proteinase, or MPP). This enzyme catalyses the following chemical reactionRelease of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2This enzyme is present the mitochondrial matrix of fungi and mammals.

Mitochondrial tRNA-uridine27/28 uracil mutase

Mitochondrial ROS

Mitontic is a town and one of the 119 Municipalities of Chiapas, in southern Mexico.As of 2010, the municipality had a total population of 11,157, up from 7,602 as of 2005. It covers an area of 82 km².As of 2010, the town of Mitontic had a population of 770. Other than the town of Mitontic, the municipality had 20 localities, the largest of which (with 2010 populations in parentheses) were: Chalam (1,345), Tzoeptic (1,295), Chimhucum (1,143), and Oxinam (1,033), classified as rural.

T.Mey.

title

Mitome-in

Country

Mitomycin

Mitochondrial DNA

n/a

水戸駅

District location in Uganda

Mitochondrial carnitine palmitoyltransferase-1

changed

In the mitochondrion, the matrix is the space within the inner membrane.The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm.The mitochondrial matrix contains the mitochondria's DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions.[1] The enzymes in the matrix facilitates reactions responsible for the production of ATP, such as the citric acid cycle, oxidative phosphorylation, oxidation of pyruvate and the beta oxidation of fatty acids.The composition of the matrix based on its structures and contents produce an environment that allows the anabolic and catabolic pathways to proceed favorably for.

水戸泉 眞幸

Mitogen-activated protein

for , , , , , and

Opilio petrensis

Mito Station (Ibaraki)

Mitochondrial DNA depletion syndrome (MDS) refers to a group of autosomal recessive disorders which cause the affected tissues to suffer from a significant drop in mitochondrial DNA. Symptoms may manifest as myopathic, hepatopathic, and/or encephalomyopathic. These syndromes affect tissue found in the muscle, liver, or both the muscle and brain, respectively.

(2E,2'E)-2,2'-(1E,2E)-propane-1,2-diylidenedihydrazinecarboximidamide

Mitoribosome

Ma. Milagros Habana-Magsaysay

Mitochondrial apoptosis-induced channel

Mitochondrial DNA (Journal)

Mitochondrial ATPase inhibitor

Mitoguardin 1

MDN

red

Mitosporic Ascomycota

Mitosevic

Fighting Spirit

Mitococha

Mitooka

Mitochondrial DNA (journal)

Mitoshirochō, Tokyo

Location of Mitoc, Botoșani

Mitogenic rays

Mitochondrial complex IV

Mitoses

Mitochondrial disorder

Mito Station (disambiguation)

Mitogenic factor

Mito Station (Osaka)

Rx-only

Mitoji Yabunaka in 2005

Mitocul Maicilor

Location in Moldova

弥刀駅

Mitosporic ascomycota

Mito Yorifusa

Mitostigma is a genus of plants in the Apocynaceae first described as a genus in 1844. It contains only one accepted species, Mitostigma castillonii, native to Jujuy Province in northwestern Argentinaformerly includedtransferred to other genera (Amitostigma, Philibertia )

The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex.The MCU is one of the primary sources of mitochondria uptake of calcium, and flow is dependent on membrane potential of the inner mitochondrial membrane and the concentration of calcium in the cytosol relative to the concentration in the mitochondria. Balancing calcium concentration is necessary to increase the cell's energy supply and regulate cell death. Calcium is balanced through the MCU in conjunction with the sodium-calcium exchanger.The MCU has a very low affinity for calcium, so the cytosolic calcium concentration needs to be approximately 5-10 uM for significant transport of calcium into the mitochondria. Mitochondria are closely associated with the endoplasmic reticulum (ER), which contains stores of cellular calcium ions for calcium signaling. The presence of 1,4,5-triphosphate (IP3) triggers the release of calcium from these intracellular stores, which creates microdomains of high calcium concentration between the ER and the mitochondria, creating the conditions for the MCU to take up calcium.Ruthenium red and Ru360 are typical reagents used to experimentally block the MCU to study its properties and role in mitochondrial signaling.

Micrograph showing ragged red fibers, a finding seen in various types of mitochondrial diseases. Muscle biopsy. Gomori trichrome stain.

Mitochondrial DNA Haplogroup

Member of the House of Representatives from the 1st District of Zambales

Mitoji Yabunaka (薮中 三十二, Yabunaka Mitoji, born January 23, 1948) is the current Japanese Vice-Minister for Foreign Affairs in charge of administration. Prior to his current position, Yabunaka served as Ministry of Foreign Affair's Asian and Oceanian Affairs Bureau Director-General. He has been a diplomat for nearly forty years.

Botoșani County

Opilio rufescens

Mitochondrial trifunctional protein

Mitochondrial membrane

Opilio similis

Profile of a middle-aged Japanese man from the chest up wearing a dark suit, blue tie, and glasses. His hair is greying to a silver.

Mitothemma is a genus of moths of the Noctuidae family.

Mitoraj

Jōban Line

Mito Nariaki

Mitogen activated protein

Mitococha Lake

Mitochondrial intermediate precursor-processing proteinase

Informa Healthcare

Mitochondrial matrix

Suigun Line

Mitostan

Mitophagy

Mitochondrial shuttle

Mitos Magsaysay

Map of the Mitocu River Basin

Mitochondrial translational release factor 1

Mitochondrial complex I

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.Mff is an outer mitochondrial membrane protein that binds to the Drp1 GTPase that controls mitochondrial fission. The Mff-Drp1 complex promotes mitochondrial fission. Mff also regulates peroxisome morphology.

Mitochondrial decay

blue

Mitong River

Mitochondrial Biology Unit

Mito, Ibaraki

PKDBCJSWQUOKDO-UHFFFAOYSA-M

Mitotane, also known as o,p'-DDD (Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease.It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it. A 2007 study of 177 patients shows a significant increase in the recurrence-free interval after radical surgery followed by mitotane when compared to surgery alone.Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reported by Schteinberg et al. include anorexia and nausea (88%), diarrhea (38%), vomiting (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%).Its trade name is Lysodren.

Mitoc is a commune in Orhei district, Moldova. It is composed of a single village, Mitoc.

Sekiwake

Mexico

None

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome

Mitopiella cinctipes is a species of harvestmen in a monotypic genus in the family Phalangiidae.

Mitochondrial DNA haplogroup

The Mitochondrial Apoptosis-Induced Channel (or MAC), is an early marker of the onset of apoptosis. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli.

Outstanding Performance

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes

Villages

Mitochordrial Eve

Mitochondrial disease is a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell. Mitochondria are found in every cell of the human body except red blood cells, and convert the energy of food molecules into the ATP that powers most cell functions.Mitochondrial diseases are sometimes (about 15% of the time) caused by mutations in the mitochondrial DNA that affect mitochondrial function.

Mitochondrial fission factor

Mitothemma

Mito line

Jeff Khonghun

Mito Kakizawa (柿沢未途, Kakizawa Mito, born January 21, 1971) is a Japanese politician and member of the House of Representatives, representing the Tokyo 15th district in the House of Representatives.Kakizawa was born in Brussels while his father Koji Kakizawa was stationed overseas with the Ministry of Finance. He grew up in Tokyo, attending Azabu High School and the University of Tokyo.

Mitogen-activated protein kinase 1

for , , and

Mitocul Maicilor ("the nuns' metochion") is a Romanian Orthodox church located at 1 Trianon Passageway in Iași, Romania. It is dedicated to Parascheva of the Balkans and to Anthony the Great.

Mitochondrial substrate carrier

Mitophyllus foveolatus male

Opilio rhododendri

Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.

Mitostigma

Mito Kakizawa

Mitomycin ball-and-stick.png

Mitochondrial genes

Mitocondria

CL0023

Mitochondrial amidoxime reducing component 1

English

Mitocu Balan

* Bus terminal

Mitochondrial complex II

Mitopus morio is a species of harvestman. It occurs in North America, Europe and Asia. It has been observed to walk using its first, third, and fourth sets of legs, using the unusually long second pair of legs to feel in front of it and probe its environment.

Mitochondrial myopathies

Mitochondrial genetics

Mitochondrial Neurogastrointestinal Encephalopathy Disease

March, 1978

In cell biology, mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei. In general, mitosis (division of the nucleus) is preceded by the S stage of interphase (during which the DNA is replicated) and is often accompanied or followed by cytokinesis, which divides the cytoplasm, organelles and cell membrane into two new cells containing roughly equal shares of these cellular components.

Mitoc, Botoșani

{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1,11-dien-8-yl}methyl carbamate

Mitochondrial disease is a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell. Mitochondria are found in every cell of the human body except red blood cells, and convert the energy of food molecules into the ATP that powers most cell functions.Mitochondrial diseases are sometimes (about 15% of the time) caused by mutations in the mitochondrial DNA that affect mitochondrial function. Other causes of mitochondrial disease are mutations in genes of the nuclear DNA, whose gene products are imported into the mitochondria (mitochondrial proteins) as well as acquired mitochondrial conditions. Mitochondrial diseases take on unique characteristics both because of the way the diseases are often inherited and because mitochondria are so critical to cell function. The subclass of these diseases that have neuromuscular disease symptoms are often called a mitochondrial myopathy.

Mitosomes

Mitochondrian

Oligolophus kulczynskii

The mitochondrial shuttles are systems used to transport reducing agents across the inner mitochondrial membrane. NADH cannot cross the membrane, but it can reduce another molecule that can cross the membrane, so that its electrons can reach the electron transport chain.The two main systems in humans are:In humans, the glycerol phosphate shuttle is primarily found in brown adipose tissue, as the conversion is less efficient, thus generating heat, which is one of the main purposes of brown fat.

Mitong River (Equatorial Guinea)

Mitochondrial transport protein

Mitotane, also known as o,p'-DDD (Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease.It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it.

Mitogen-activated protein kinase 12

Mitogen-activated protein kinase 9

Mitochondrial permeability pore

NTSC 625-line colour

The mitochondrial shuttles are systems used to transport reducing agents across the inner mitochondrial membrane. NADH cannot cross the membrane, but it can reduce another molecule that can cross the membrane, so that its electrons can reach the electron transport chain.The two main systems in humans are:In humans, the glycerol phosphate shuttle is primarily found in brown adipose tissue, as the conversion is less efficient, thus generating heat, which is one of the main purposes of brown fat. It is primarily found in babies, though it is present in small amounts in adults around the kidneys and on the back of our necks. The malate-aspartate shuttle is found in much of the rest of the body.

above

Mitogen-activated protein kinase kinase 1

Mitosis modulators

Mitochondrial 21S rRNA methyltransferase

Uganda

Oligolophus vagans

Mitochondria DNA

Hepatic

for Tomobe, Tsuchiura, , and Ueno

Mitomycinum

Mitooka Eiji

Mitochondrial genetic

Mitocul Dragomirnei

Modern humans

Mitopetalum

Mitogenetic ray

Mitochondrial encephalomyopathies

Mitomi, Yamanashi

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Further experiments will be needed to identify the specific subunit localization. Sequence analysis identified three transcript variants that encode two different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q.

Mitosis phase

FY2014

Mitochondria (single)

Commune and village

United Nationalist Alliance

Mitoizumi

Mitochondrial complex III

Mitochondriopathy

Mitos y Leyendas

Mitochondrial pyruvate carrier 2

In the mitochondrion, the matrix is the space within the inner membrane.The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm.The mitochondrial matrix contains the mitochondria's DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions.[1] The enzymes in the matrix facilitates reactions responsible for the production of ATP, such as the citric acid cycle, oxidative phosphorylation, oxidation of pyruvate and the beta oxidation of fatty acids.The composition of the matrix based on its structures and contents produce an environment that allows the anabolic and catabolic pathways to proceed favorably for. The electron transport chain and enzymes in the matrix play a large role in the citric acid cycle and oxidative phosphorylation. The citric acid cycle produces NADH and FADH2 through oxidation that will be reduced in oxidative phosphorylation to produce ATP.The cytosolic, intermembrane space, compartment has a water content of 3.8 μl/mg protein, while the mitochondrial matrix 0.8 μl/mg protein. It is not known how mitochondria maintain osmotic balance across the inner mitochondrial membrane, although the membrane contains aquaporins that are believed to be conduits for regulated water transport. Mitochondrial matrix has a pH of about 7.8. Mitochondrial DNA was discovered by Nash and Margit in 1963. One to many double stranded mainly circular DNA is present in mitochondrial matrix. Mitochondrial DNA is 1% of total DNA of a cell. It is rich in Guanine and Cytosine content. Mitochondria of mammals have 55s ribosomes.

Mitochondrial inner matrix

for , , , and

NBK1179

Mitological

Mitogen-activated protein kinase 3

Mitome Tadao

Mitomycin c

Mitochondria

Mitochondrial replacement

Mitochondrial Matrix

Location in Uganda

Mitoizumi Takasago

Mitocu Bălan

Mito Kouzou

September 2008

Mitokomon

Mitochondrial toxicity

Mitochondrial Blues

JWBOIMRXGHLCPP-UHFFFAOYSA-N

Mitonyssoides

Countries

Mito Koumon

In enzymology, a mitochondrial protein-transporting ATPase (EC 3.6.3.51) is an enzyme that catalyzes the chemical reactionATP + H2O ⇌ {\displaystyle \rightleftharpoons } ADP + phosphateThus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances.

Mitochondrial Eve

Although commonly depicted as bean-like structures, mitochondria form a highly dynamic network within most cells where they constantly undergo fission and fusion. Mitochondria can divide by prokaryotic binary fission and since they require mitochondrial DNA for their function, fission is coordinated with DNA replication. Some of the proteins that are involved in mitochondrial fission have been identified and some of them are associated with mitochondrial diseases. Mitochondrial fission has significant implications in stress response and apoptosis.

Mitochondrial electron transport chain

Opilio grossipes

Oral

Mitosis Promoting Factor

Mitochondrial neurogastrointestinal encephalomyopathy

Mitochondrial fission