Imatinib, sold under the brand names Gleevec and Glivec, used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Due in large part to the development of Gleevec and related drugs having a similar mechanism of action, the five year survival rate for people with chronic myeloid leukemia nearly doubled from 31% in 1993 (before Gleevec's 2001 FDA approval) to 59% for those diagnosed between 2003 and 2009.
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For King & Country, stylized as for KING & COUNTRY and formerly known as Joel & Luke as well as Austoville, is a Christian pop duo composed of Australian brothers Joel (born 5 June 1984) and Luke Smallbone (born 22 October 1986). The Nashville-based brothers' 2012 debut record Crave, has received praise, and the brothers were declared by Billboard as one of the "New Artists To Watch" for 2012.

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IMATINIB

Wilmington Savings Fund Society

PDB complex

Ball-and-stick model of the imatinib molecule
Rx-only

Luke Skelton

Louis Henri

Luke Skelton & Seb Harvey

Crystallographic structure of tyrosine-protein kinase ABL complexed with imatinib .

Michael O'Dwyer
Thomas Crawley

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York St John University Rowing Club

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Louis Henri Joseph de Bourbon

The 2022 United States elections will be held on Tuesday, November 8, 2022 in the middle of the term of the President who is elected in 2020. During this mid-term election year, all 435 seats in the United States House of Representatives and 34 of the 100 seats in the United States Senate will be contested. 38 state and territorial governorships and numerous other state and local elections will also be contested.

POM

The 2022 United States elections will be held on Tuesday, November 8, 2022 in the middle of the term of the President who is elected in 2020. During this mid-term election year, all 435 seats in the United States House of Representatives and 34 of the 100 seats in the United States Senate will be contested. 38 state and territorial governorships and numerous other state and local elections will also be contested. This will be the first election affected by the redistricting that will follow the 2020 United States Census.

Feel the rythym, feel the beat, come on YSJ row your feet

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Imatinib, sold under the brand names Gleevec and Glivec, used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Due in large part to the development of Gleevec and related drugs having a similar mechanism of action, the five year survival rate for people with chronic myeloid leukemia nearly doubled from 31% in 1993 (before Gleevec's 2001 FDA approval) to 59% for those diagnosed between 2003 and 2009. Median survival for imatinib-treated people with gastrointestinal stromal tumors (GIST) is nearly 5 years compared to 9 to 20 months in the pre-imatinib-era.Compared to older drugs imatinib has a relatively benign side effect profile, allowing many patients to live a normal lifestyle. Imatinib is a tyrosine-kinase inhibitor. It kills cancer cells by blocking the action of tyrosine kinases. In order to survive, cells need signaling through proteins (signal cascade) to keep them alive. Some of the proteins in this cascade use a phosphate group as an "on" switch. This phosphate group is added by a tyrosine kinase enzyme. In healthy cells, these tyrosine kinase enzymes are turned on and off as needed. In Ph-positive CML cells, one tyrosine kinase enzyme, BCR-Abl, is stuck on the "on" position, and keeps adding phosphate groups. Imatinib blocks this BCR-Abl enzyme, and stops it from adding phosphate groups. As a result, these cells stop growing, and even die by a process of cell death (apoptosis). Because the BCR-Abl tyrosine kinase enzyme exists only in cancer cells and not in healthy cells, imatinib works as a form of targeted therapy—only cancer cells are killed through the drug's action. In this regard, imatinib was one of the first cancer therapies to show the potential for such targeted action, and is often cited as a paradigm for research in cancer therapeutics.It is on the World Health Organization's List of Essential Medicines, a list of the medications needed to cover the majority of health care needs in a health system. The developers of imatinib were awarded the Lasker Award in 2009 and the Japan Prize in 2012. In October, 2016, Novartis received the prestigious Prix Galien Foundation’s "Discovery of the Decade" Award for Best Pharmaceutical Product for Gleevec®. Gleevec is the beta crystalline form of imatinib mesilate, the mesylate salt of imatinib. Physicians have written that the cost of imatinib, averaging $120,000 a year in 2016, is excessive. In the USA, the patent protecting the active principle expired on 4 January 2015 while the patent protecting the beta crystal form of the active principal ingredient will expire on 23 May 2019. In India, the patent was rejected in an Indian Supreme Court decision in 2013.

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November 2016

Brad Simmons

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For King & Country, stylized as for KING & COUNTRY and formerly known as Joel & Luke as well as Austoville, is a Christian pop duo composed of Australian brothers Joel (born 5 June 1984) and Luke Smallbone (born 22 October 1986). The Nashville-based brothers' 2012 debut record Crave, has received praise, and the brothers were declared by Billboard as one of the "New Artists To Watch" for 2012. American Songwriter described them as "Australian's answer to Coldplay."SUSIE Magazine raves, "It takes only one listen to the brothers' rich, upbeat, alternative sounds and thoughtful lyrics to understand their sudden popularity."They describe their philosophy as such:"The power of music can impact our mood, emotions, our day. But when you merge the strength of music with the heart, hope and passion of the Gospel... it has the ultimate power not only to change someone's day, but to impact them for eternity. This is why we write music and sing songs - we hope that people will be moved, encouraged and stirred to live a life for Someone greater than themselves."They cite U2, Mutemath, OneRepublic, The Beatles, The Goo Goo Dolls, and Switchfoot, as well as film scores such as those from Braveheart and Gladiator, as their musical influences.

One Mississippi is an American comedy television series created by comedian Tig Notaro. The pilot episode aired on Amazon Prime on November 5, 2015, and was picked up for a full series after positive feedback from audiences. Diablo Cody and Louis C.K. worked on the series as executive producers. One Mississippi premiered on September 9, 2016. On November 14, 2016 Amazon renewed the show for a second season.

Glivec
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