Independence is a 1976 docudrama film directed by John Huston and starring Eli Wallach, Pat Hingle, and Anne Jackson. E.G. Marshall narrates. Independence was produced for the U.S. National Park Service on the occasion of the Bicentennial of the United States in 1976. In less than 30 minutes, visitors to Independence National Historical Park get a quick and dramatic overview of the political events that took place in Philadelphia between 1774 and 1800.

Tebanicline (ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analog of the potent poison dart frog-derived compound epibatidine, which is about 200 times stronger than morphine as an analgesic, but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. Tebanicline progressed to Phase II clinical trials in humans, but was dropped from further development due to unacceptable incidence of gastrointestinal side effects. However, further research in this area is ongoing, and the development of nicotinic acetylcholine receptor agonists is ongoing. No agents from this class have successfully completed human clinical trials due to their unacceptable side effect profiles. Research in the area continues.
* Corrections to the chemical structure had resulted in Sazetidine A.
* (SUVN-911) was also discovered.
* C12(C(C1)CNC2)COC3=CC=C(N=C3)Cl (c.f. ).

Johnny C. Gibbons