The 2020–21 season was the 106th season of the Isthmian League, which is an English football competition featuring semi-professional and amateur clubs from London, East and South East England. The league operates four divisions, the Premier Division at Step 3, and three divisions, North, South Central and South East at Step 4 of the National League System. This is the third season since the former South Division was subdivided into the South Central and South East divisions. The league is also known as the Pitching In League under a sponsorship deal with Entain, formerly GVC Holdings. The allocations for Steps 3 and 4 for season 2020–21 were announced by the FA on 21 July 2020. No changes were made to the constitutions of any of the divisions within the Isthmian League. Due to the restrictions on clubs' ability to play matches in the lockdowns associated with the COVID-19 pandemic, competitions at Steps 3–6 were curtailed on 24 February 2021. The scheduled restructuring of non-league will take place at the end of the season, with a new division to be added to Northern Premier League at step 4 for 2021–22, which will result in some reallocations into or out of, and promotions to, the Isthmian League's Step 4 divisions.

Thandiwe Banda is a Zambian political science teacher who served as the First Lady of Zambia from June 2008 until September 2011. Banda, who was in her 30s when she took over the position in 2008, was the youngest First Lady in Zambia's history. She is the current wife of former President Rupiah Banda.

The 2020–21 season was the 106th season of the Isthmian League, which is an English football competition featuring semi-professional and amateur clubs from London, East and South East England. The league operates four divisions, the Premier Division at Step 3, and three divisions, North, South Central and South East at Step 4 of the National League System. This is the third season since the former South Division was subdivided into the South Central and South East divisions. The league is also known as the Pitching In League under a sponsorship deal with Entain, formerly GVC Holdings.