Josué Smith Solar (December 8, 1867 – 1938) was a Chilean architect.

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Joseph Alper

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Joseph Seth Alper (born 1946) is a former professor of chemistry at the University of Massachusetts, Boston. He is known for his work analyzing genetic discrimination and other issues related to human genetics research. He is a founding member of the Genetic Screening Study Group. He received his bachelor's degree from Harvard University in 1963 and his Ph.D. from Yale University in 1968. He did his postdoc in the laboratory of Robert Silbey at the Massachusetts Institute of Technology from 1968 to 1970.

Down's syndrome, Down's, trisomy 21

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Josué Smith Solar

Santa Rosa, California's Cultural Heritage Board recommends sites for Designated Landmark status. The City Council makes the final decisions regarding designations. Santa Rosa's designations are independent of state and federal designations. The County of Sonoma's historic landmark designations intentionally exclude sites within the cities in the County.

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Niko Kranjčar

Architect

Down syndrome

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Philosophy

Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an eight- or nine-year-old child, but this can vary widely. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45. The extra chromosome is believed to occur by chance, with no known behavioral activity or environmental factor that changes the probability. Down syndrome can be identified during pregnancy by prenatal screening followed by diagnostic testing or after birth by direct observation and genetic testing. Since the introduction of screening, Down syndrome pregnancies are often aborted. Regular screening for health problems common in Down syndrome is recommended throughout the person's life. There is no cure for Down syndrome. Education and proper care have been shown to improve quality of life. Some children with Down syndrome are educated in typical school classes, while others require more specialized education. Some individuals with Down syndrome graduate from high school, and a few attend post-secondary education. In adulthood, about 20% in the United States do paid work in some capacity, with many requiring a sheltered work environment. Support in financial and legal matters is often needed. Life expectancy is around 50 to 60 years in the developed world with proper health care. Down syndrome is one of the most common chromosome abnormalities in humans. It occurs in about 1 in 1,000 babies born each year. In 2015, Down syndrome was present in 5.4 million individuals globally and resulted in 27,000 deaths, down from 43,000 deaths in 1990. It is named after British doctor John Langdon Down, who fully described the syndrome in 1866. Some aspects of the condition were described earlier by French psychiatrist Jean-Étienne Dominique Esquirol in 1838 and French physician Édouard Séguin in 1844. The genetic cause of Down syndrome was discovered in 1959.

Census-designated places in Coconino County, Arizona

The small Indian mongoose (Herpestes auropunctatus) is a mongoose species native to South and Western Asia that has been introduced to many regions of the world.

Niko Kranjčar (pronounced [nǐːko krâɲtʃaːr]; born 13 August 1984) is a Croatian former professional footballer. He primarily played as an attacking midfielder, but could also operate as a winger or second striker. He has played with clubs in his homeland, playing for Dinamo Zagreb before sparking controversy by making a move to their fierce rivals Hajduk Split in January 2005. A transfer to England with Portsmouth soon followed in August 2006, and after several years of attempting to hold on to their key players, Portsmouth decided to sell him at the start of the 2009–10 season, opening the way for a move to Tottenham in September 2009, where he was reunited with his former manager at Portsmouth, Harry Redknapp. He moved on to Ukrainian side Dynamo Kyiv in 2012, where he spent a two year period on loan at Queens Park Rangers, reuniting with Redknapp for a third time. He finished his career with brief spells in the United States with New York Cosmos and Scotland with Rangers before retiring in 2018. Hailed as the next Robert Prosinečki, Kranjčar was given his international debut by his father Zlatko in August 2004, and went on to represent his country at the 2006 FIFA World Cup, UEFA Euro 2008 and UEFA Euro 2012. In total he won 81 caps for the Croatia national team, scoring 16 goals in the process. His final match for the national team was on 15 October 2013, as he missed the 2014 FIFA World Cup because of a leg injury.

Santa Rosa historic landmarks

Niko Kranjčar (pronounced [nǐːko krâɲtʃaːr]; born 13 August 1984) is a Croatian former professional footballer. He primarily played as an attacking midfielder, but could also operate as a winger or second striker.

Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an eight- or nine-year-old child, but this can vary widely.