Everglades virus (EVEV) is an alphavirus included in the Venezuelan equine encephalitis virus complex. The virus circulates among rodents and vector mosquitoes and sometimes infects humans, causing a febrile illness with occasional neurological manifestations. The virus is named after the Everglades, a region of subtropical wetlands in southern Florida. The virus is endemic to the U.S. state of Florida, where its geographic range mirrors that of the mosquito species . Hispid cotton rat and cotton mouse are considered important reservoir hosts of Everglades virus. Most clinical cases of infection occur in and around the city of Miami.