The University Times

The Kerry Minor Hurling Championship (known for sponsorship reasons as Keane’s SuperValu Killorglin Kerry County Minor Hurling Championship) is an annual hurling competition organised by the Kerry County Board of the Gaelic Athletic Association for the top Under 18 hurling teams in the county of Kerry in Ireland. The first championship was held in 1947 and was won by a North Kerry selection comprising players from the Crotta O'Neill's, Lixnaw and Ballyduff clubs.

RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the Orexin 1 receptor (KE = 8.5nM) and lacks significant affinity for the Orexin 2 receptor (KE = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine.

Wilhelmina Holladay

Gypsy

Facioscapulohumeral muscular dystrophy

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"Examination Day" is the first segment of the sixth episode from the first season (1985–86) of the television series The Twilight Zone. The segment is based on the short story "Examination Day" by Henry Slesar.

Jonacatepec

Jathi Ratnalu (transl. Jewels of the Nation) is a 2021 Indian Telugu-language comedy-drama film written and directed by Anudeep KV. Produced by Nag Ashwin under Swapna Cinema, the film stars Naveen Polishetty, Priyadarshi, Rahul Ramakrishna, and Faria Abdullah while Murali Sharma and Naresh play supporting roles. The story of the comedy film revolves around three happy-go-lucky men. They land up in jail and learn a new path to attain glory in life. It was released theatrically on 11 March 2021.. The film received positive reviews, highlighting film’s witty humor and comical performances of the lead cast.

In computer networking, a proxy server is a server application or appliance that acts as an intermediary for requests from clients seeking resources from servers that provide those resources. A proxy server thus functions on behalf of the client when requesting service, potentially masking the true origin of the request to the resource server.

Right Wing

Kerry Minor Hurling Championship
The Kerry Minor Hurling Championship (known for sponsorship reasons as Keane’s SuperValu Killorglin Kerry County Minor Hurling Championship) is an annual hurling competition organised by the Kerry County Board of the Gaelic Athletic Association for the top Under 18 hurling teams in the county of Kerry in Ireland. The first championship was held in 1947 and was won by a North Kerry selection comprising players from the Crotta O'Neill's, Lixnaw and Ballyduff clubs. The series of games are played during the summer months, with the county final usually being played in Austin Stack Park as part of a double-header with the Senior Championship Final. A number of championships were awarded by the Co. Board following an objection, often due to the presence of an over-age or illegal player. The ultimate outcome of the 1967 championship is not known with the final subject to Co, Board and Munster Council hearings and appeals. The 1970 championship was unfinished.

Proxy server

Paul Nicholas Miller (born August 11, 1988), better known by his online alias GypsyCrusader, is an American alt-right political commentator, activist, streamer, investigative journalist, and former Muay Thai fighter, trainer, and coach. A convicted felon, he is known for his livestreams that feature him cosplaying as an array of different characters including The Joker, The Riddler, Mario, and others while he pushes his political beliefs on strangers for shock value. He is also known for his advocacy of white supremacy and neo-Nazism and he has been tied to multiple alt-right and far-right organizations and movements like the Boogaloo movement and the Proud Boys.

Tetris

Facioscapulohumeral muscular dystrophy (FSHD) is a type of muscular dystrophy that preferentially weakens the skeletal muscles of the face (Latin: facio), those that position the scapula (scapulo), and those in the upper arm, overlying the humerus bone (humeral). Weakness of the scapular muscles causes an abnormally positioned scapula (winged scapula). Other areas of the body usually develop weakness as well, such as the abdomen and lower leg, causing foot drop. The two sides of the body are often affected unequally. Symptoms typically begin in early childhood and become noticeable in the teenage years, with 95% of affected individuals manifesting disease by age 20 years. Non-muscular manifestations of FSHD include hearing loss and blood vessel abnormalities in the back of the eye. FSHD is caused by complex genetic changes involving the DUX4 gene. In those without FSHD, DUX4 is expressed (ie: turned on) in early human development and later repressed (ie: turned off) in mature tissues. In FSHD, DUX4 is inadequately turned off, which can be caused by several different mutations, the most common being deletion of DNA in the region surrounding DUX4. This mutation is termed "" and defines FSHD type 1 (FSHD1), making up 95% of FSHD cases. FSHD due to other mutations is classified as FSHD type 2 (FSHD2). Regardless of which mutation is present, disease can only result if the individual has a 4qA allele, which is a common variation in the DNA next to DUX4. Up to 30% of FSHD cases are due to a new mutation, which then is able to be passed on to children. FSHD1 follows an autosomal dominant inheritance pattern, meaning each child of an affected individual has a 50% chance of also being affected. How DUX4 expression causes muscle damage is unclear. Expression of DUX4 gene produces DUX4 protein, whose function is to modulate hundreds of other genes, many of which are involved in muscle function. Diagnosis is by genetic testing. There is no known cure for FSHD. No pharmaceuticals have proven effective for altering the disease course. Symptoms can be addressed with physical therapy, bracing, and reconstructive surgery. Surgical fixation of the scapula to the thorax is effective in reducing shoulder symptoms in select cases. FSHD is the third most common genetic disease of skeletal muscle (Duchenne/Becker muscular dystrophy being first and myotonic dystrophy being second), affecting 1 in 8,333 to 1 in 15,000 people. Prognosis is extremely variable, with many never facing significant limitations, although up to 20% of affected individuals become severely disabled, requiring use of a wheel chair or mobility scooter. Life expectancy is generally not affected, except in rare cases of respiratory insufficiency. The first description of an individual with FSHD is an autopsy report from 1852, although FSHD was not distinguished as a disease until the 1870s and 1880s when French physicians Landouzy and Dejerine followed a family affected by it; thus FSHD is sometimes referred to as Landouzy–Dejerine muscular dystrophy. In 1991, the association of most cases with the tip of chromosome 4 was established, which was discovered to be due to D4Z4 contraction in 1993. DUX4 was discovered in 1999, but it was not until 2010 that the genetic mechanism causing its expression was elucidated. In 2012, the predominant mutation of FSHD2 was discovered. In 2014, researchers published the first proposed pathophysiology definition of the disease and four viable therapeutic targets for possible intervention points.

Adolph Tidemand

Jathi Ratnalu

GypsyCrusader

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Over Horizon

List of awards and nominations received by Im Yoon-ah

Articles needing additional references from June 2018

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List of soap opera villains

Examination Day

Paul Nicholas Miller

political commentator

The following deaths of notable individuals occurred in 2021. Names are reported under the date of death, in alphabetical order by surname or pseudonym.A typical entry reports information in the following sequence:
* Name, age, country of citizenship at birth, subsequent nationality (if applicable), what subject was noted for, cause of death (if known), and reference.

RTIOX-276

Adolph Tidemand (14 August 1814 – 8 August 1876) was a noted Norwegian romantic nationalism painter. Among his best known paintings are Haugianerne (The Haugeans; 1852) and Brudeferd i Hardanger (The Bridal Procession in Hardanger; 1848), painted in collaboration with Hans Gude.

Articles with dead external links from March 2021

Jonacatepec de Leondro Valle is a city in the Mexican state of Morelos. . The city serves as the municipal seat for the surrounding municipality of the same name. The municipality reported 15,690 inhabitants in the year 2015 census. Jonacatepec has 98 km2 (38 sq. miles), which represents 1.97% of the total area of the state. It is 1,290 meters (3,967 feet) above sea level.

This page details the all-time statistics, records, and other achievements pertaining to the Toronto Raptors.

Alexander N'Doumbou

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European route E 263 is a Class B road part of the International E-road network. It runs only through Estonia, begins in Tallinn and ends in Luhamaa, Võru County, and shares exactly the same route as Estonian national road 2. Route: Tallinn – Tartu – Võru – Luhamaa. Its total length is 288.5 km (179.3 mi).

The University Times (often abbreviated as UT or the UT) is a student newspaper. Published from Trinity College Dublin, it is financially supported by Trinity College Dublin Students' Union but maintains a mutually agreed policy of editorial independence. In 2017, it won the award for best all-around non-daily student newspaper in the world, as judged by the US-based Society of Professional Journalists.

Red Dawn is a 1984 American action film directed by John Milius, with a screenplay by Kevin Reynolds and Milius. It stars Patrick Swayze, Charlie Sheen, C. Thomas Howell, Lea Thompson, Jennifer Grey, Ben Johnson, Harry Dean Stanton, Ron O'Neal, William Smith, and Powers Boothe. It was the first film to be released in the U.S. with a PG-13 rating (under the modified rating system introduced on July 1, 1984).
Red Dawn is a 1984 American action film directed by John Milius, with a screenplay by Kevin Reynolds and Milius. It stars Patrick Swayze, Charlie Sheen, C. Thomas Howell, Lea Thompson, Jennifer Grey, Ben Johnson, Harry Dean Stanton, Ron O'Neal, William Smith, and Powers Boothe. It was the first film to be released in the U.S. with a PG-13 rating (under the modified rating system introduced on July 1, 1984). The film depicts a United States that has been invaded by the Soviet Union and its Cuban and Nicaraguan allies. However, the onset of World War III is in the background and not fully elaborated. The story follows a group of American high school students who resist the occupation with guerrilla warfare, naming themselves the "Wolverines", after their high school mascot.

This is a list of awards and nominations received by South Korean singer and actress Im Yoon-ah.

Over Horizon is a side-scrolling shoot 'em up video game developed by Pixel for the Nintendo Entertainment System, and published by Hot B in 1991.

Deaths in 2021

Short description matches Wikidata

Investigative journalist

Primordial nuclide

Wilhelmina Cole

Jonacatepec de Leondro Valle is a city in the Mexican state of Morelos. . The city serves as the municipal seat for the surrounding municipality of the same name. The municipality reported 15,690 inhabitants in the year 2015 census. The name Jonacatepec comes from Nahuatl language and was written Xonakatepek . Its etymological roots come from Xonaka-tl (onion), Tepe-tl (hill), k apócope from the adverb ko (place) and means "on the hill where there are onions". Leondro Valle is in reference to a supporter of the Plan de Ayutla of 1857 which opposed the dictatorship of Antonio López de Santa Anna. Leondro Valle was from the town of Jonacatepec. Jonacatepec has 98 km2 (38 sq. miles), which represents 1.97% of the total area of the state. It is 1,290 meters (3,967 feet) above sea level.

Video game franchises introduced in 1984

Red Dawn

Paul Miller

The University Times (often abbreviated as UT or the UT) is a student newspaper. Published from Trinity College Dublin, it is financially supported by Trinity College Dublin Students' Union but maintains a mutually agreed policy of editorial independence. In 2017, it won the award for best all-around non-daily student newspaper in the world, as judged by the US-based Society of Professional Journalists. In 2015, the newspaper's website had over one million unique readers for the first time. Its print edition, which consists of a broadsheet newspaper, magazine and culture supplement, is published every three weeks during the academic year.

Facioscapulohumeral muscular dystrophy (FSHD) is a type of muscular dystrophy that preferentially weakens the skeletal muscles of the face (Latin: facio), those that position the scapula (scapulo), and those in the upper arm, overlying the humerus bone (humeral). Weakness of the scapular muscles causes an abnormally positioned scapula (winged scapula). Other areas of the body usually develop weakness as well, such as the abdomen and lower leg, causing foot drop. The two sides of the body are often affected unequally. Symptoms typically begin in early childhood and become noticeable in the teenage years, with 95% of affected individuals manifesting disease by age 20 years. Non-muscular manifestations of FSHD include hearing loss and blood vessel abnormalities in the back of the eye.

In computer networking, a proxy server is a server application or appliance that acts as an intermediary for requests from clients seeking resources from servers that provide those resources. A proxy server thus functions on behalf of the client when requesting service, potentially masking the true origin of the request to the resource server. Instead of connecting directly to a server that can fulfill a requested resource, such as a file or web page, the client directs the request to the proxy server, which evaluates the request and performs the required network transactions. This serves as a method to simplify or control the complexity of the request, or provide additional benefits such as load balancing, privacy, or security. Proxies were devised to add structure and encapsulation to distributed systems.

A villain is an "evil" character in a story, whether a historical narrative or, especially, a work of fiction. In soap operas, the villain, sometimes called a "bad guy", is an antagonist, tending to have a negative effect on other characters. A female villain is sometimes called a villainess or "bad girl". Random House Unabridged Dictionary defines villain as "a cruelly malicious person who is involved in or devoted to wickedness or crime; scoundrel; or a character in a play, novel, or the like, who constitutes an important evil agency in the plot". An early use of the term soap opera villain was in 1942.

Landouzy–Dejerine muscular dystrophy, FSHMD, FSH

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European route E263

Toronto Raptors accomplishments and records

A villain is an "evil" character in a story, whether a historical narrative or, especially, a work of fiction. In soap operas, the villain, sometimes called a "bad guy", is an antagonist, tending to have a negative effect on other characters. A female villain is sometimes called a villainess or "bad girl". Random House Unabridged Dictionary defines villain as "a cruelly malicious person who is involved in or devoted to wickedness or crime; scoundrel; or a character in a play, novel, or the like, who constitutes an important evil agency in the plot". An early use of the term soap opera villain was in 1942. Tom Conroy from Media Life Magazine noted that "On soap operas, sometimes a perfectly nice regular character will suddenly turn into a villain. Viewers are rarely alerted to the change beforehand." Shelley Fralic of the Winnipeg Free Press described the "first-class villain" of soap as: "Ruthless magnate. Serial groom. Charming rogue. Unrepentant schemer. Demanding paterfamilias. Defier of death. Tough, impatient, decisive, magnetic and infuriating. The blackest of blackguards." A writer for Inside Soap magazine warned that "soap psychos" are often overly keen on their partners, keep them separated from their families, have strange things hidden in secret rooms, will attempt to kill their partner's ex-partner, and are fond of fire or high places and named a number of characters from EastEnders, Emmerdale and Coronation Street who have behaved in such ways. Debra Hale, writing about the fate of villains for the Associated Press, said that "Sometimes, a villain becomes so evil he's beyond redemption and must be killed or imprisoned", but noted that "some villains are just too delectable to kill." The following lists soap opera characters who have been described as villainous, evil, bad guys or baddies.

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