Notable persons who were born, grew up in or established their fame in Regina, Saskatchewan:
* Velma Abbott (1929–1987), All-American Girls Professional Baseball League player'
* Dan Achen, guitarist, producer, co-founder of alternative rock band Junkhouse
* Mathew Dumba, NHL player
* John Joseph "Jack" Malone, ace fighter pilot in WWI, lived in Regina before enlisting
* Dick Assman, gas station attendant facetiously given fame on the David Letterman television show
* Joseph Baggaley (c. 1884–1918) trade unionist
* Bonnie Baker (1918–2003), All-American Girls Professional Baseball League player
* Doris Barr (1921–2009), All-American Girls Professional Baseball League player
* Catherine Bennett (born 1920), All-American Girls Professional Baseball League player
* Red Berenson, Team Canada 1972, former NHL player and coach, Head Coach of the University of Michigan Ice Hockey Team
* Mike Blaisdell, former NHL player
* Bob Boyer, visual artist, elder, university professor
* Tyler Bozak, NHL player
* Beverley Breuer, actor whose credits include Scary Movie 4
* Garth Butcher, NHL player
* Jock Callander, IHL all-time scoring leader
* Terry Cochrane, Canadian football player
* Charlie David, actor
* Stu Davis, (aka "Canada's Cowboy Troubadour"), singer/guitarist, known internationally for songwriting, recordings, radio and television
* Robert Dirk, former NHLer
* Shirley Douglas, actor, daughter of T.C. Douglas; mother of Kiefer Sutherland
* T.C. Douglas, CCF premier 1944–1961; later leader of the federal New Democratic Party
* Duke Dukowski, former NHLer
* Bob Hughes (1944–2013), Sports Writer, CFL Hall of Fame Inductee
* Jordan Eberle, NHL player for the Edmonton Oilers and New York Islanders
* Murray Edwards, one of the richest Canadians
* Jack Engle, hot rodder and custom camshaft grinder, founder of Engle Cams (to American parents)
* Joe Fafard, sculptor and artist
* Leanne Franson, cartoonist and illustrator
* Jackie Friesen, assistant coach with the Wisconsin Badgers women's ice hockey team
* Genevieve George (1927–2002), All-American Girls Professional Baseball League player
* Chris Getzlaf, CFL player
* Ryan Getzlaf, NHL player
* Dirk Graham, NHL player
* Roland Groome, first licensed commercial pilot in Canada
* Jack Hamilton (1886–1976), Canadian ice hockey and multi-sport executive
* Kevin Hanson, basketball player and coach
* Scott Hartnell, NHL player
* Jamie Heward, NHL player
* Bill Hicke, NHL player with the Montreal Canadiens, New York Rangers, Oakland Seals, and the Pittsburgh Penguins
* Roger Ing, artist
* Into Eternity, progressive metal band
* Dick Irvin, Jr., Hockey Night in Canada broadcaster
* Colin James, six-time Juno award-winning blues-rock musician
* Christine Jewitt (born 1926), All-American Girls Professional Baseball League player
* Arleene Johnson (1924–2017), All-American Girls Professional Baseball League player
* Marguerite Jones (1917–1995), All-American Girls Professional Baseball League player
* Daisy Junor (1919–2012), All-American Girls Professional Baseball League player
* Connie Kaldor, singer
* Donald M. Kendrick, Calgary native, choral conductor and teacher at the University of Saskatchewan, Regina Campus, in the 1970s
* Morgan Klimchuk, AHL player for the Belleville Senators
* Chris Kunitz, NHL player
* Brock Lesnar, professional wrestler currently signed with WWE; residence in Regina
* Elyse Levesque, actress, born and raised in Regina
* Sarah Lind, actor
* Daniel Maslany, actor
* Tatiana Maslany, actor
* Mike Maurer, CFL player
* Ethel McCreary, All-American Girls Professional Baseball League player
* Mick McGeough, NHL referee
* Frances Gertrude McGill, pioneering forensic pathologist and criminologist
* Mark McMorris, snowboarding, bronze medalist winter Olympic winner on 2018 Winter Olympics Pyeongchang and 18 time Xgames medalist.
* Gerry Minor, former NHL player
* Garth Murray, NHL player
* Maye Musk, model and mother of entrepreneur, Elon Musk
* Steve Nash, NBA player
* Zarqa Nawaz, creator of the CBC sitcom Little Mosque on the Prairie
* Erik Nielsen, federal politician, former deputy prime minister
* Leslie Nielsen, actor whose credits include Airplane!, Naked Gun and Scary Movie 4
* Paul Owen, cricketer
* Michael Peers, Archbishop of Qu'Appelle; Primate of the Anglican Church of Canada 1986–2004
* Janet Perkin (1921–2012), professional baseball and curling player
* Jason Plumb, popular musician formerly with the Waltons
* Logan Pyett, AHL player (Detroit Red Wings organization) and member of gold-medal winning Team Canada in 2005–2006 (U18 Junior World Cup) and 2007–08 (World Junior Championship)
* Staff Barootes (1918–2000), Senator
* Erika Ritter, playwright and broadcaster
* Martha Rommelaere (1922–2011), All-American Girls Professional Baseball League player
* Karl Schubach, vocalist of metalcore band Misery Signals
* Jack Semple, blues guitarist
* Lyldoll, singer
* Mike Sillinger, NHL player
* Charley Stis (1884–1979), professional baseball player, manager and umpire
* Stephen Surjik, television and motion picture director whose credits include The Kids in the Hall and Wayne's World 2
* Dione Taylor, jazz singer
* Dave Tippett, former NHL player, NHL coach
* Darren Veitch, former NHL player
* Mildred Warwick (1922–2006), All-American Girls Professional Baseball League player
* Elizabeth Wicken (1927–2011), All-American Girls Professional Baseball League player
* Doug Wickenheiser (1961–99), NHL player
* Ron Adam, CFL defensive back
* Jon Ryan (1982), NFL player