Herman Marion "Hermie" Sadler III (born April 24, 1969) is an American professional stock car racing driver, announcer, and professional wrestling promoter from Emporia, Virginia. He is currently a NASCAR driver with occasional appearances for the Virginia Lottery at Martinsville Speedway, Richmond International Raceway, and Bristol Motor Speedway; in 2019, he drove the No. 93 Chevrolet Camaro in the NASCAR Xfinity Series for RSS Racing. He was also a pit reporter with Fox Sports 1 for Xfinity and NASCAR Gander Outdoors Truck Series broadcasts.

Elliott Sadler

Kanye West announced his 2020 United States presidential election campaign through Twitter on July 4, 2020, Independence Day. On July 16, 2020, the campaign filed a Statement of Candidacy with the Federal Election Commission. He entered the election after missing at least six states' deadlines to appear on the ballot as a third-party candidate. In the first week of August, West missed the deadline to appear on the ballot in the vast majority of states. West won't be on enough state ballots to get 270 electoral votes, so he cannot win the presidential election. West has selected Michelle Tidball, a Christian preacher from Wyoming, as his running mate. West's rhetoric has been described by Al Jazeera as having "a Republican-leaning, pro-Black religious platform".

All articles with unsourced statements

Magnum opus (alchemy)

2020 United States Senate election in North Carolina

Pages with citations using unsupported parameters

Chad Haga

Redirects from modifications

"Blood Sweat & Tears" (Korean: 피 땀 눈물; RR: Pi ttam nunmul; Japanese: 血、汗、涙; Hepburn: Chi, ase, namida) is a song recorded in two languages (Korean and Japanese) by South Korean boy band BTS. It was written by "Hitman" Bang, Kim Do-hoon, RM, Suga, J-Hope, and Pdogg, with the latter of the six solely handling production. The Korean version was released on October 10, 2016, as the lead single from the band's second studio album Wings (2016) by Big Hit Entertainment. The Japanese version of the song was released on May 10, 2017 through Universal Music Japan, as a single album that included B-side tracks "Spring Day" and "Airplane Pt. 2", both also in Japanese. Musically, "Blood Sweat & Tears" is a moombahton, trap, and tropical house song with influences of dancehall and reggaeton. The track's lyrics address the pain of addictive love. The song received generally positive reviews from music critics, who were favourable towards its production, refreshing sound and the band's vocal delivery. It was also likened to the musical styles of Major Lazer and Justin Bieber. It earned a nominated for the Song of the Year at the 2016 Mnet Asian Music Awards and appeared on the decade-end lists of Billboard and GQ. Commercially, the Korean version of "Blood Sweat & Tears" debuted at number one on the Gaon Digital Chart, becoming the band's first number-one song on the chart. As of May 2019, the single has sold over 2.5 million copies in South Korea. The Japanese version debuted and peaked at number one on the Oricon Singles Chart, becoming the 22nd best-selling single of 2017 in Japan. It received a certified platinum certification from by the Recording Industry Association of Japan (RIAJ) for shipments of over 250,000 copies. Two music videos were filmed for the single, one for the Korean version and one for the Japanese version; the first video was directed by YongSeok Choi and premiered on Big Hit's YouTube channel on October 10, 2017. Inspired by Hermann Hesse's Demian (1991), the symbolism-heavy video depicts the band exploring a museum and performing choreography. The second video featuring psychedelic and neon colours, was uploaded to Universal Music Japan's YouTube channel on May 10, 2017. BTS promoted the song with televised live performances on various South Korean music programs in 2016, including M! Countdown, Music Bank, and Inkigayo. It was also included on the set list of their The Wings Tour (2017).

Hansel (March 12, 1988 – June 13, 2017) was an American Thoroughbred racehorse who won the final two legs of the U.S. Triple Crown races in 1991 and was voted the Eclipse Award for Outstanding 3-Year-Old Male Horse. Out of the mare Count on Bonnie, his sire was Woodman, a Champion 2-year-old colt in Ireland who was a son of the influential Champion sire Mr. Prospector. Woodman also sired the 1994 Breeders' Cup Juvenile and Preakness Stakes winner, Timber Country, as well as the 1999 Canadian Champion 3-Year-Old Colt and Queen's Plate winner, Woodcarver. Hansel's owner was banker Joe Allbritton, who raced him under his Lazy Lane Farm banner.

The following is a timeline of the COVID-19 pandemic in the United States.

C-Class biography articles

2020–21 FC Akhmat Grozny season

C-Class Women writers articles

Bolsover South is a former railway station in Carr Vale, Bolsover, Derbyshire, England.

Israeli people by city and occupation

Jeffrey Tyler Burton (born June 29, 1967), nicknamed The Mayor, is an American former professional stock car racing driver and current racing commentator. He scored 21 career victories in the NASCAR Cup Series, including two Coca-Cola 600s in 1999 and 2001 and the 1999 Southern 500. He currently serves as a color commentator for NBC Sports, having joined them upon their return to their coverage of NASCAR. His son Harrison Burton currently competes in the Xfinity Series and part-time in the NASCAR Camping World Truck Series. His brother Ward Burton and his nephew Jeb Burton have also competed in the NASCAR Cup Series.

Massive Attack

Keith Scott (born 28 October 1953) is an Australian voice actor, comedian, impressionist and animation historian.

Cell signaling

* animation historian

Kannur International Airport

Women in China

Old Town Transit Center

Poetry (derived from the Greek poiesis, "making") is a form of literature that uses aesthetic and often rhythmic qualities of language—such as phonaesthetics, sound symbolism, and metre—to evoke meanings in addition to, or in place of, the prosaic ostensible meaning. Poetry has a long history – dating back to prehistoric times with hunting poetry in Africa, and to panegyric and elegiac court poetry of the empires of the Nile, Niger, and Volta River valleys. Some of the earliest written poetry in Africa occurs among the Pyramid Texts written during the 25th century BCE. The earliest surviving Western Asian epic poetry, the Epic of Gilgamesh, was written in Sumerian. Early poems in the Eurasian continent evolved from folk songs such as the Chinese Shijing; or from a need to retell oral epics, as with the Sanskrit Vedas, the Zoroastrian Gathas, and the Homeric epics, the Iliad and the Odyssey. Ancient Greek attempts to define poetry, such as Aristotle's Poetics, focused on the uses of speech in rhetoric, drama, song, and comedy. Later attempts concentrated on features such as repetition, verse form, and rhyme, and emphasized the aesthetics which distinguish poetry from more objectively-informative prosaic writing. Poetry uses forms and conventions to suggest differential interpretations of words, or to evoke emotive responses. Devices such as assonance, alliteration, onomatopoeia, and rhythm may convey musical or incantatory effects. The use of ambiguity, symbolism, irony, and other stylistic elements of poetic diction often leaves a poem open to multiple interpretations. Similarly, figures of speech such as metaphor, simile, and metonymy establish a resonance between otherwise disparate images—a layering of meanings, forming connections previously not perceived. Kindred forms of resonance may exist, between individual verses, in their patterns of rhyme or rhythm. Some poetry types are unique to particular cultures and genres and respond to characteristics of the language in which the poet writes. Readers accustomed to identifying poetry with Dante, Goethe, Mickiewicz, or Rumi may think of it as written in lines based on rhyme and regular meter. There are, however, traditions, such as Biblical poetry, that use other means to create rhythm and euphony. Much modern poetry reflects a critique of poetic tradition, testing the principle of euphony itself or altogether forgoing rhyme or set rhythm.In an increasingly globalized world, poets often adapt forms, styles, and techniques from diverse cultures and languages. A Western cultural tradition (which extends at least from Homer to Rilke) associates the production of poetry with inspiration – often by a Muse (either classical or contemporary).

Year 694 (DCXCIV) was a common year starting on Thursday (link will display the full calendar) of the Julian calendar. The denomination 694 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.

Unassessed Women writers articles

All Creatures Great and Small is an upcoming 2020 television series based upon the books about a Yorkshire vet, written by Alf Wight under the pen name of James Herriot. The series, which also consists of a special Christmas episode, has been filmed in conjunction with the 50th anniversary of the publication of the first book in the James Herriot series.

Mustafa Raza Khan Qadri (1892–1981) was an Indian Muslim scholar and author, and leader of the Sunni Barelvi movement following the death of its founder, his father Ahmed Raza Khan. He was known as Mufti-Azam-i-Hind to his followers. In a biography compiled by Moulana Muhammad Afthab Cassim Razvi he is referred to as Mufti-e-Azam-e-Hind.

Biography with signature

Kanye West announced his 2020 United States presidential election campaign through Twitter on July 4, 2020, Independence Day. On July 16, 2020, the campaign filed a Statement of Candidacy with the Federal Election Commission. He entered the election after missing at least six states' deadlines to appear on the ballot as a third-party candidate. In the first week of August, West missed the deadline to appear on the ballot in the vast majority of states. West won't be on enough state ballots to get 270 electoral votes, so he cannot win the presidential election. West has selected Michelle Tidball, a Christian preacher from Wyoming, as his running mate. West's rhetoric has been described by Al Jazeera as having "a Republican-leaning, pro-Black religious platform". West has qualified for ballot access in three states and has held a rally in South Carolina, though failing to make it on the ballot there. On August 4, 2020, West withdrew his petition to appear on New Jersey's ballot after his petition was challenged on legal grounds, with challenges alleging forged signatures on the submitted petition. On August 7, the state of Illinois (which requires 2,500 valid signatures) determined that only 1,200 of the 3,128 signatures sent by Kanye West's campaign are valid, meaning West will not be on his home state's ballot. Also on August 7, it was reported that multiple challenges have been made to West's petition to appear on the Wisconsin ballot. One such challenge suggests numerous problems with West's nomination papers, including incorrect addresses and fake or fraudulent signatures, such as "Mickey Mouse" and "Bernie Sanders." It also included affidavits from six individuals who said they were duped into putting their names on West's paperwork.

Lifespring, founded in 1974, was a private, for-profit, New Age-human potential organization. Lifespring stated they trained more than 400,000 people through its ten centers across the country. Lifespring encountered significant controversy; various academic articles published in psychology journals in the 1970s and 1980s characterized Lifespring's training methods as "deceptive and indirect techniques of persuasion and control", and featured allegations that Lifespring was a cult that coerced members from leaving. After these allegations were highlighted in a 1987 article in the Washington Post and local television reporting in communities where Lifespring had a significant presence, Lifespring changed its name to the "Legacy Center." The Legacy Center was also met with controversy, and when it was under investigation by the North Carolina Attorney General's office for allegedly defrauding its members, it changed its name to the "Gratitude Center." John Hanley Sr., Robert White, Randy Revell, and Charlene Afremow founded Lifespring in 1974. As of October 1987, Hanley owned 92.7 percent of the company. Prior to Lifespring, Hanley worked for the company Holiday Magic. He and the other founders also worked for Mind Dynamics with Werner Erhard, the founder of est, which became the basis for Landmark Education. Lifespring concentrated on how people experience each other, whereas est dealt with changing the way people experience themselves. However, there were many similarities between the two. The former Director for Corporate Affairs of Lifespring, Charles "Raz" Ingrasci, also worked with Erhard, promoting an est mission to the USSR and the Hunger Project. Ingrasci is now President of the Hoffman Institute which offers programs such as the Hoffman Quadrinity Process which some regard as similar to Lifespring.

Intel 4004

Kanye West 2020 presidential campaign

Springfield College is a private college in Springfield, Massachusetts. The institution confers undergraduate and graduate degrees.Known as the birthplace of basketball, the sport was invented there in 1891 by Canadian-American graduate student James Naismith. The college's philosophy of "humanics" "calls for the education of the whole person—in spirit, mind, and body—for leadership in service to others." It is symbolized by a balanced inverted triangle.

Members of the Contract Sejm

Chad Haga (; born August 26, 1988) is an American professional road racing cyclist, who currently rides for UCI WorldTeam Team Sunweb.

The Intel 4004 is a 4-bit central processing unit (CPU) released by Intel Corporation in 1971. It was the first commercially produced microprocessor, and the first in a long line of Intel CPUs. The chip design, implemented with the MOS silicon gate technology, started in April 1970, and was created by Federico Faggin who led the project from beginning to completion in 1971. Marcian Hoff formulated and led the architectural proposal in 1969, and Masatoshi Shima contributed to the architecture and later to the logic design. The first delivery of a fully operational 4004 occurred in March 1971 to Busicom Corp. of Japan for its 141-PF printing calculator engineering prototype (now displayed in the Computer History Museum – Mountain View, Ca) . This calculator for which the 4004 was originally

Candidates for speedy deletion as abandoned drafts or AfC submissions

Rick Mast

Elliott William Barnes Sadler (born April 30, 1975) is an American former professional stock car racing driver. He last competed part-time in the NASCAR Xfinity Series, driving the No. 10 Chevrolet Camaro for Kaulig Racing. Sadler is one of 31 drivers who have at least one win in each of NASCAR's top three series. Sadler was born in Emporia, Virginia; he is the younger brother of former NASCAR driver Hermie Sadler.

Redirects for discussion from August 2020

In biology, cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. A signal is an entity that codes or conveys information. Biological processes are complex molecular interactions that involve a lot of signals. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing may cause diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, clinicians may treat diseases more effectively and, theoretically, researchers may develop artificial tissues.

Mutimir (Serbian: Мутимир, Greek: Μουντιμῆρος) was prince of Serbia from ca. 850 until 891. He defeated the Bulgar army, allied himself with the Byzantine emperor and ruled the first Serbian Principality when the Christianization of the Serbs took place and the Eparchy of Ras was established. He was the eldest son of Knez Vlastimir, great-great-grandson of the Unknown Archont, who managed to unite the Serb tribes into a state. He initially ruled together with his two younger brothers, but they revolted against him and he exiled them to Bulgaria, as guarantors of peace.

Unknown-importance Women writers articles

Università degli Studi di Bergamo

Hagasaki

Lifespring

All redirects for discussion

Overland Campaign

University of Bergamo

Marvel's Avengers is an upcoming action-adventure video game co-developed by Crystal Dynamics and Eidos-Montréal and published by Square Enix. Based on the Marvel Comics superhero team the Avengers, the game is inspired by the long-running comic book mythology and adaptations in other media. The game's main storyline takes place five years after A-Day, a celebratory day for the Avengers wherein a tragedy resulted in death and destruction, and the Avengers were blamed. The team is forced to reassemble to save the world from peril in the form of A.I.M. led by MODOK which threatens ending the world from superpowers. The game features an online co-op mode, allowing players to assemble a team of heroes of their own. The initial playable characters include Steve Rogers / Captain America, Tony Stark / Iron Man, Bruce Banner / Hulk, Thor, Natasha Romanova / Black Widow, and Kamala Khan / Ms. Marvel, with more becoming available to players post-launch. The game will be released for Stadia, Microsoft Windows, PlayStation 4, and Xbox One on 4 September 2020. However, if preordered, players will be able to play the beta starting on 8 August 2020. The game will also be released on the PlayStation 5 and Xbox Series X when both consoles launch, with PlayStation 4 players and Xbox One players being able to upgrade to the next-gen version for free.

Timeline of the COVID-19 pandemic in the United States

Robeston Wathen Quarries

The University of Bergamo (Italian: Università degli Studi di Bergamo), known colloquially as UniBg, is an Italian public university located in Bergamo, Italy. It was founded on 11 December 1968 and is organized in seven departments, three campuses and forty-one degree courses.

Politicians from Beersheba

Pachino

"Blood Sweat & Tears" (Korean: 피 땀 눈물; RR: Pi ttam nunmul; Japanese: 血、汗、涙; Hepburn: Chi, ase, namida) is a song recorded in two languages (Korean and Japanese) by South Korean boy band BTS. It was written by "Hitman" Bang, Kim Do-hoon, RM, Suga, J-Hope, and Pdogg, with the latter of the six solely handling production. The Korean version was released on October 10, 2016, as the lead single from the band's second studio album Wings (2016) by Big Hit Entertainment. The Japanese version of the song was released on May 10, 2017 through Universal Music Japan, as a single album that included B-side tracks "Spring Day" and "Airplane Pt. 2", both also in Japanese. Musically, "Blood Sweat & Tears" is a moombahton, trap, and tropical house song with influences of dancehall and reggaeton. The track's

All Creatures Great and Small (2020 TV series)

Jeff Burton

Nazi (disambiguation)

The Great Work (Latin: Magnum opus) is an alchemical term for the process of working with the prima materia to create the philosopher's stone. It has been used to describe personal and spiritual transmutation in the Hermetic tradition, attached to laboratory processes and chemical color changes, used as a model for the individuation process, and as a device in art and literature. The magnum opus has been carried forward in New Age and neo-Hermetic movements which sometimes attached new symbolism and significance to the processes. The original process philosophy has four stages:

* Voice actor

Springfield College

American racing drivers

AfD debates (Biographical)

Richard Lee Rudd (born September 12, 1956), nicknamed "The Rooster," is an American former racing driver. He is the uncle of actor Skeet Ulrich and former NASCAR Busch Series driver Jason Rudd. He retired in 2007 with 23 career wins. He was named the 2006 Virginian of the Year and was inducted into the Virginia Sports Hall of Fame in 2007. In October 2010, he was selected to the Hampton Roads Sports Hall of Fame, which honors those who have contributed to sports in southeastern Virginia.

Stub-Class biography articles

Redirects from alternative names

Genentech brands

Ricky Rudd

437 "Park and Ride" lot spaces, with 350+ overflow spaces

The 2020–21 FC Akhmat Grozny season is the 12th successive season that the club will play in the Russian Premier League, the highest tier of association football in Russia.

Temporary maintenance holdings

Global warming
The rising average temperature of Earth's climate system, called global warming, is driving changes in rainfall patterns, extreme weather, arrival of seasons, and more. Collectively, global warming and its effects are known as climate change. While there have been prehistoric periods of global warming, observed changes since the mid-20th century have been unprecedented in rate and scale. The Intergovernmental Panel on Climate Change (IPCC) concluded that "human influence on climate has been the dominant cause of observed warming since the mid-20th century". These findings have been recognized by the national science academies of major nations and are not disputed by any scientific body of national or international standing. The largest human influence has been the emission of greenhouse gases, with over 90% of the impact from carbon dioxide and methane. Fossil fuel burning is the principal source of these gases, with agricultural emissions and deforestation also playing significant roles. Temperature rise is enhanced by self-reinforcing climate feedbacks, such as loss of snow cover, increased water vapour, and melting permafrost. Land surfaces are heating faster than the ocean surface, leading to heat waves, wildfires, and the expansion of deserts. Increasing atmospheric energy and rates of evaporation are causing more intense storms and weather extremes, damaging infrastructure and agriculture. Surface temperature increases are greatest in the Arctic and have contributed to the retreat of glaciers, permafrost, and sea ice. Environmental impacts include the extinction or relocation of many species as their ecosystems change, most immediately in coral reefs, mountains, and the Arctic. Surface temperatures would stabilize and decline a little if emissions were cut off, but other impacts will continue for centuries, including rising sea levels from melting ice sheets, rising ocean temperatures, and ocean acidification from elevated levels of carbon dioxide. Countries work together on climate change under the umbrella of the United Nations Framework Convention on Climate Change (UNFCCC), which has near-universal membership. The goal of the convention is to "prevent dangerous anthropogenic interference with the climate system". The IPCC has told policy makers that there is much greater risk to human and natural systems if warming goes above 1.5 °C (2.7 °F) compared to pre-industrial levels. Under the Paris Agreement, nations are making climate pledges to reduce greenhouse gas (GHG) emissions, but those promises - assuming nations follow through - would still allow global warming to reach about 2.8 °C (5.0 °F) by 2100. To limit warming to 1.5 °C (2.7 °F), methane emissions would need to decrease to near-zero levels and carbon dioxide emissions would need to reach net-zero by the year 2050. Mitigation efforts to address global warming include the development and deployment of low carbon energy technologies, policies to reduce fossil fuel emissions, reforestation, forest preservation, as well as the development of potential climate engineering technologies. Societies and governments are also working to adapt to current and future global warming impacts, including improved coastline protection, better disaster management, and the development of more resistant crops.

* impressionist

Marvel's Avengers is an upcoming action-adventure video game co-developed by Crystal Dynamics and Eidos-Montréal and published by Square Enix. Based on the Marvel Comics superhero team the Avengers, the game is inspired by the long-running comic book mythology and adaptations in other media. The game's main storyline takes place five years after A-Day, a celebratory day for the Avengers wherein a tragedy resulted in death and destruction, and the Avengers were blamed. The team is forced to reassemble to save the world from peril in the form of A.I.M. led by MODOK which threatens ending the world from superpowers.

AfD debates

Dan Ryan (politician)

The 2020 United States Senate election in North Carolina will be held on November 3, 2020, to elect a member of the United States Senate to represent the State of North Carolina, concurrently with the 2020 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections. North Carolina is one of just five states holding presidential, gubernatorial, and senatorial elections concurrently in 2020. On March 3, 2020, incumbent Thom Tillis and former State Senator Cal Cunningham won their respective parties' primaries. The winner will immediately become the state's senior senator following the retirement of Richard Burr in 2023.

Poetry (derived from the Greek poiesis, "making") is a form of literature that uses aesthetic and often rhythmic qualities of language—such as phonaesthetics, sound symbolism, and metre—to evoke meanings in addition to, or in place of, the prosaic ostensible meaning. A Western cultural tradition (which extends at least from Homer to Rilke) associates the production of poetry with inspiration – often by a Muse (either classical or contemporary).

Articles with unsourced statements

CS1 maint: others

Candidates for speedy deletion

Blood Sweat & Tears

Marvel's Avengers

Catholic University of Belgium

In biology, cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. A signal is an entity that codes or conveys information. Biological processes are complex molecular interactions that involve a lot of signals. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing may cause diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, clinicians may treat diseases more effectively and, theoretically, researchers may develop artificial tissues. Systems biology studies the underlying structure of cell-signaling networks and how changes in these networks may affect the transmission and flow of information (signal transduction). Such networks are complex systems in their organization and may exhibit a number of emergent properties, including bistability and ultrasensitivity. Analysis of cell-signaling networks requires a combination of experimental and theoretical approaches, including the development and analysis of simulations and modeling. Long-range allostery is often a significant component of cell-signaling events. Signaling agents could be physical agents like mechanical pressure, voltage, temperature, light etc. or chemical agents like peptides, steroids, terpenoids, etc. Better to say, every molecule has some or some signaling consequences. it may be food material or pathogen-associated patterns, or it may be oxygen-level or carbon di oxide or it may be specially biosynthesised signaling molecules like hormones and ferromones (ektohormones). Signaling molecules greatly vary in their physico chemical properties such as solubilities (hydrophobic or hydrophillic) Some of the signaling molecules are gaseous, such as nitric oxide. All cells receive and respond to signals from their surroundings. This is accomplished by a variety of signal molecules that are secreted or expressed on the surface of one cell and bind to a receptor expressed by the other cells, thereby integrating and coordinating the function of the many individual cells that make up organisms. Each cell is programmed to respond to specific extracellular signal molecules. Extracellular signaling usually entails the following steps: 1.
* Synthesis and release of the signaling molecule by the signaling cell; 2.
* Transport of the signal to the target cell; 3.
* Binding of the signal by a specific receptor leading to its activation; 4.
* Initiation of signal-transduction pathways. Synthesis involves various biosynthetic pathways, and happens in specific time and place. Sometimes the signal molecules are released from the cell and sometimes they are not released at all, such as cellular localisation signals and DNA damage signals. Such intracellular signaling networks work within the cell. Sometimes signal molecules are released through various ways like membrane-diffusion, exocytosis, cell-rupture etc. In some cases the signal molecules remain attached with cell-surface, a mode that helps in juxtacrine signaling (discussed below). Sometimes signal molecules require activation, such as through proteolytic cleavage, covalent modification, etc. Path of the signal may be intracellular or inter-cellular. The inter-cellular signaling is also called cell-to-cell communication. It can be short or long distance. Based on nature of this path of signal molecule from source to target cell; the signaling pathways are classified into autocrine, juxtacrine, intracrine, paracrine and endocrine (discussed below) Receptors play a key role in cell signaling. Receptors help in recognising the signal molecule (legand). However some receptor molecules interact with physical agent like Voltage, Light, etc. Receptor molecules are generally proteins but in some cases they may be RNA. Receptors may locate at cell surface, or interior of the cell such as cytosol, the organelles and Nucleus (especially the transcription factors). Usually the cell surface receptors bind membrane-impermeable signal molecules, but sometimes they also interact with membrane permeable signal molecules. A key step in signaling is to removal and degradation of the signal molecule. Sometimes the receptor is also degraded. Neurotransmitter reuptake is a mechanism of signaling molecule removal that is commonly seen in nervous system, and is a target of some class of prescription psychiatric medications. Binding with the ligand causes conformational change in the receptor, that leads to further transmission of signaling. Due to conformational change, the receptor may either show an enzymic activity (called enzymic receptor), or a ion channel opening or closing activity (called a ligand gated channel receptor). Sometimes the receptors themselves does not contain any enzymic or channel like domain but they are linked with enzyme or transporter. Some receptors (the nuclear-cytoplasmic superfamily) have a different mechanism, once they bind with ligand, they change their DNA binding properties and cellular localisation properties. Result of enzymic activity of the receptor usually lead to recruitment of another molecular change which again cause another molecular change, thus it causes a signal transduction "cascade". These intermediates often forms a second messenger system. Within the signal transduction cascade there may be enzymes and transporters which work similar way as receptors. These enzymic activities include covalent modifications like proteolytic cleavage, phosphorylation/dephosphorylation, methylation/demethylation, ubiquitinylation/deubiquitinylation etc. These are part of regulatory strategies. The reactions happen on very specific sites on the substrates. An important phenomena that happens in the intracellular portion of signaling is signal amplification. through which, even if a little number of receptor is activated, subsequently a very large number of molecules get activated in the downstream. Inhibition and activation (through either Feedforward or feedback) and signal crosstalk are also important phenomena in signal transduction chains. Sometimes feedback relation causes biological oscillations , . On prolonged stimulus or over-exposure with the signal, causes a mechanism called adaptation or desensitisation, through which extra signal is ignored. Re-activation or resensitisation may happen after the excess stimulus is removed for a prolonged period.

Robeston Wathen Quarries is a Site of Special Scientific Interest (or SSSI) in Pembrokeshire, South Wales, immediately to the north of the village of Robeston Wathen. It has been designated as a Site of Special Scientific Interest since January 1967 in an attempt to protect its fragile geological elements. The site has an area of 1.64 hectares and is managed by Natural Resources Wales.

Grand Mufti of India

St. Mary Magdalene's Church

Star Wars: The Last Jedi

Blood Sweat & Tears (song)

San Diego, California

After Last Season

Hansel (horse)

UNIBG

The rising average temperature of Earth's climate system, called global warming, is driving changes in rainfall patterns, extreme weather, arrival of seasons, and more. Collectively, global warming and its effects are known as climate change. While there have been prehistoric periods of global warming, observed changes since the mid-20th century have been unprecedented in rate and scale.

The Overland Campaign, also known as Grant's Overland Campaign and the Wilderness Campaign, was a series of battles fought in Virginia during May and June 1864, in the American Civil War. Lt. Gen. Ulysses S. Grant, general-in-chief of all Union armies, directed the actions of the Army of the Potomac, commanded by Maj. Gen. George G. Meade, and other forces against Confederate Gen. Robert E. Lee's Army of Northern Virginia. Although Grant suffered severe losses during the campaign, it was a strategic Union victory. It inflicted proportionately higher losses on Lee's army and maneuvered it into a siege at Richmond and Petersburg, Virginia, in just over eight weeks. Crossing the Rapidan River on May 4, 1864, Grant sought to defeat Lee's army by quickly placing his forces between Lee and Richmond and inviting an open battle. Lee surprised Grant by attacking the larger Union army aggressively in the Battle of the Wilderness (May 5–7), resulting in heavy casualties on both sides. Unlike his predecessors in the Eastern Theater, however, Grant did not withdraw his army following this setback, but instead maneuvered to the southeast, resuming his attempt to interpose his forces between Lee and Richmond. Lee's army was able to get into position to block this movement. At the Battle of Spotsylvania Court House (May 8–21), Grant repeatedly attacked segments of the Confederate defensive line, hoping for a breakthrough, but the only results were again heavy losses for both sides. Grant maneuvered again, meeting Lee at the North Anna River (Battle of North Anna, May 23–26). Here, Lee held clever defensive positions that provided an opportunity to defeat portions of Grant's army, but illness prevented Lee from attacking in time to trap Grant. The final major battle of the campaign was waged at Cold Harbor (May 31 – June 12), in which Grant gambled that Lee's army was exhausted and ordered a massive assault against strong defensive positions, resulting in disproportionately heavy Union casualties. Resorting to maneuver a final time, Grant surprised Lee by stealthily crossing the James River, threatening to capture the city of Petersburg, the loss of which would doom the Confederate capital. The resulting Siege of Petersburg (June 1864 – March 1865) led to the eventual surrender of Lee's army in April 1865 and the effective end of the Civil War. The campaign included two long-range raids by Union cavalry under Maj. Gen. Philip Sheridan. In a raid toward Richmond, Confederate cavalry commander Maj. Gen. J.E.B. Stuart was mortally wounded at the Battle of Yellow Tavern (May 11). In a raid attempting to destroy the Virginia Central Railroad to the west, Sheridan was thwarted by Maj. Gen. Wade Hampton at the Battle of Trevilian Station (June 11–12), the largest all-cavalry battle of the war.
The Overland Campaign, also known as Grant's Overland Campaign and the Wilderness Campaign, was a series of battles fought in Virginia during May and June 1864, in the American Civil War. Lt. Gen. Ulysses S. Grant, general-in-chief of all Union armies, directed the actions of the Army of the Potomac, commanded by Maj. Gen. George G. Meade, and other forces against Confederate Gen. Robert E. Lee's Army of Northern Virginia. Although Grant suffered severe losses during the campaign, it was a strategic Union victory. It inflicted proportionately higher losses on Lee's army and maneuvered it into a siege at Richmond and Petersburg, Virginia, in just over eight weeks.

1991 Ukrainian independence referendum

Mustafa Raza Khan Qadri

2 side platforms, 1island platform(San Diego Trolley)

Keith Scott (voice actor)

Catalina Island bison herd

A referendum on the Act of Declaration of Independence was held in Ukraine on 1 December 1991. An overwhelming majority of 92.3% of voters approved the declaration of independence made by the Verkhovna Rada on 24 August 1991.

Hansel

Wolof

Lesser Poland Voivodeship

The lives of women in China have changed significantly due to the late Qing Dynasty reforms, the changes of the Republican period, the Chinese Civil War, and the rise of the People's Republic of China. Achievement of women’s liberation has been on the agenda of the Communist Party of China since the beginning of the PRC. Mao Zedong famously said, "Women hold up half the sky." In 1995, President Jiang Zemin made gender equality official state policy. Although China has been tremendously successful in achieving gender equality, women still suffer a lower status compared with men.

Bolsover South

Avengers (2020 video game)

Mid-importance Women writers articles

The Intel 4004 is a 4-bit central processing unit (CPU) released by Intel Corporation in 1971. It was the first commercially produced microprocessor, and the first in a long line of Intel CPUs. The chip design, implemented with the MOS silicon gate technology, started in April 1970, and was created by Federico Faggin who led the project from beginning to completion in 1971. Marcian Hoff formulated and led the architectural proposal in 1969, and Masatoshi Shima contributed to the architecture and later to the logic design. The first delivery of a fully operational 4004 occurred in March 1971 to Busicom Corp. of Japan for its 141-PF printing calculator engineering prototype (now displayed in the Computer History Museum – Mountain View, Ca) . This calculator for which the 4004 was originally designed and built as a custom chip was first commercially available in July 1971. The 4004 was the first random logic circuit integrated in one chip using the MOS (metal–oxide–semiconductor) silicon gate technology (SGT). It was the most advanced integrated circuit (IC) design undertaken up until then. Hoff, head of Intel’s Application Research department, had formulated an architectural proposal consisting of a block architecture with an instruction set during 1969, while talking with Busicom engineers led by Shima and with the assistance of Stan Mazor. Hoff and Mazor were not MOS chip designers and did not participate in the actual design or development of the 4004. The chip design was realized independently in the MOS department, different from Application Research. It could only be realized by a designer with deep knowledge of MOS process technology and of the new SGT. Faggin was hired at Intel in April 1970 from Fairchild Semiconductor to be the project leader and designer of the 4004 and he transferred to manufacturing a fully functional chip in March 1971. Faggin brought to Intel his mastery of the SGT that he had invented at Fairchild (in 1968) and used it to develop his novel methodology for random chip design that was key to making the first and all the early Intel microprocessors. Shima, representing Busicom, was engaged with Hoff and Mazor in the architectural phase during 1969 and he also assisted Faggin with the final logic design for 6 months in 1970. In November 1971, with the prophetic advert "Announcing a new era in integrated electronics", the 4004 was made commercially available to the general market. The 4004 was the first monolithic processor, fully integrated in one small chip. Such a feat of integration was made possible by the use of the new silicon gate technology for integrated circuits, originally developed by Faggin (with Tom Klein) at Fairchild Semiconductor in 1968, which allowed twice the number of random-logic transistors and an increase in speed by a factor of five compared to the incumbent MOS aluminum gate technology. Faggin also invented the bootstrap load with silicon gate and the "buried contact", improving speed and circuit density compared with aluminum gate. The 4004 microprocessor, the 4001 ROM, 4002 RAM, and 4003 Shift Register constituted the four chips in the Intel MCS-4 chip set. With these components, small computers with varying amounts of memory and I/O facilities could be built.

Invirase

Ghazi Aridi

Richard K. Mast (born March 4, 1957) is a former NASCAR driver. He competed in both the Winston Cup and Busch Series before retiring in 2002. He holds a business administration degree from Blue Ridge Community College.

Comune di Pachino

4005 Taylor Street

Ghazi Hani Aridi (born 17 October 1954) is a Lebanese politician who has held various cabinet portfolios. He was the minister of public works and transportation from 13 June 2011 to December 2013.

Pachino (Italian pronunciation: [paˈkiːno]; Sicilian: Pachinu [paˈciːnʊ]) is a town and comune in the Province of Syracuse, Sicily (Italy). The name derives from the Latin word bacchus, which is the Roman god of wine, and the word vinum, which means wine in Latin; originally the town was named Bachino which eventually was changed to Pachino when, in Sicily, Italian became the official spoken and written language.

The history of baseball can be broken down into various aspects: by era, by locale, by organizational-type, game evolution, well as by political and cultural influence. The game evolved from older bat-and-ball games already being played in England by the mid-18th century. This game was brought by immigrants to North America, where the modern version developed. By the late 19th century, baseball was widely recognized as the national sport of the United States. Baseball is popular in North America and parts of Central and South America, the Caribbean, and East Asia, particularly in Japan, South Korea, and Taiwan.

Star Wars: The Last Jedi (also known as Star Wars: Episode VIII – The Last Jedi) is a 2017 American epic space opera film written and directed by Rian Johnson. It is the second installment of the Star Wars sequel trilogy, following The Force Awakens (2015), and it is the eighth episode of the nine-part "Skywalker saga". It was produced by Lucasfilm and distributed by Walt Disney Studios Motion Pictures. The film's ensemble cast includes Mark Hamill, Carrie Fisher, Adam Driver, Daisy Ridley, John Boyega, Oscar Isaac, Andy Serkis, Lupita Nyong'o, Domhnall Gleeson, Anthony Daniels, Gwendoline Christie, and Frank Oz in returning roles, with Kelly Marie Tran, Laura Dern, and Benicio del Toro joining the cast. It features the first posthumous film performance by Fisher, who died in December 2016

Universitas Studiorum Bergomensis

Mutimir

History of baseball

Poetry

Wolof language

Bolsover South railway station

Mustafa Raza Khan

Star Wars: The Last Jedi (also known as Star Wars: Episode VIII – The Last Jedi) is a 2017 American epic space opera film written and directed by Rian Johnson. It is the second installment of the Star Wars sequel trilogy, following The Force Awakens (2015), and it is the eighth episode of the nine-part "Skywalker saga". It was produced by Lucasfilm and distributed by Walt Disney Studios Motion Pictures. The film's ensemble cast includes Mark Hamill, Carrie Fisher, Adam Driver, Daisy Ridley, John Boyega, Oscar Isaac, Andy Serkis, Lupita Nyong'o, Domhnall Gleeson, Anthony Daniels, Gwendoline Christie, and Frank Oz in returning roles, with Kelly Marie Tran, Laura Dern, and Benicio del Toro joining the cast. It features the first posthumous film performance by Fisher, who died in December 2016, and the film is dedicated to her memory. The Last Jedi follows Rey as she seeks the aid of Luke Skywalker, in hopes of turning the tide for the Resistance in the fight against Kylo Ren and the First Order, while General Leia Organa, Finn, and Poe Dameron attempt to escape a First Order attack on the dwindling Resistance fleet. The Last Jedi is part of a new trilogy of films announced after Disney's acquisition of Lucasfilm in October 2012. It was produced by Lucasfilm president Kathleen Kennedy and Ram Bergman and executive produced by The Force Awakens director J. J. Abrams. John Williams, composer for the previous episodic films, returned to compose the score. A number of scenes were filmed at Skellig Michael in Ireland during pre-production in September 2015, but principal photography began at Pinewood Studios in England in February 2016 and wrapped that July. Post-production was completed in September 2017. The Last Jedi had its world premiere at the Shrine Auditorium in Los Angeles on December 9, 2017, and was released in the United States on December 15, 2017. It grossed over $1.3 billion worldwide, becoming the highest-grossing film of 2017, the seventh-highest-grossing film in North America, and the ninth-highest-grossing film of all time during its theatrical run. It is also the second-highest-grossing Star Wars film and turned a net profit of over $417 million. The film received positive reviews, with praise for its ensemble cast, musical score, visual effects, action sequences, and emotional weight. The film received four nominations at the 90th Academy Awards, including Best Original Score and Best Visual Effects, as well as two nominations at the 71st British Academy Film Awards. A sequel, The Rise of Skywalker, was released on December 20, 2019.

Pachino (Italian pronunciation: [paˈkiːno]; Sicilian: Pachinu [paˈciːnʊ]) is a town and comune in the Province of Syracuse, Sicily (Italy). The name derives from the Latin word bacchus, which is the Roman god of wine, and the word vinum, which means wine in Latin; originally the town was named Bachino which eventually was changed to Pachino when, in Sicily, Italian became the official spoken and written language. It was founded in 1760 by the nobles Starrabba, princes of Giardinelli and marquises of Rudinì, on the hill of the feud of , where a preexisting tower was built in 1494. Pachino was invaded in 1943 by the British 8th Army as a part of the allied invasion of Sicily.

The Catalina Island bison herd has existed for nearly a century. This herd of American Bison roam and were supposedly first imported to California's Catalina Island in 1924 for the silent film version of Zane Grey's Western tale, The Vanishing American. However, the 1925 version of "The Vanishing American" does not contain any bison and shows no terrain that resembles Catalina, according to Jim Watson, columnist for The Catalina Islander newspaper. According to Watson, an October 6, 1938 article in The Catalina Islander attributes the bison arrival to the filming of "The Thundering Herd," a silent film released in 1925.

Lifespring, founded in 1974, was a private, for-profit, New Age-human potential organization. Lifespring stated they trained more than 400,000 people through its ten centers across the country. Lifespring encountered significant controversy; various academic articles published in psychology journals in the 1970s and 1980s characterized Lifespring's training methods as "deceptive and indirect techniques of persuasion and control", and featured allegations that Lifespring was a cult that coerced members from leaving. After these allegations were highlighted in a 1987 article in the Washington Post and local television reporting in communities where Lifespring had a significant presence, Lifespring changed its name to the "Legacy Center." The Legacy Center was also met with controversy, and w

Hermie Sadler

Keith Scott

Mutimir of Serbia

* comedian

The Great Work (Latin: Magnum opus) is an alchemical term for the process of working with the prima materia to create the philosopher's stone. It has been used to describe personal and spiritual transmutation in the Hermetic tradition, attached to laboratory processes and chemical color changes, used as a model for the individuation process, and as a device in art and literature. The magnum opus has been carried forward in New Age and neo-Hermetic movements which sometimes attached new symbolism and significance to the processes. The original process philosophy has four stages:
* nigredo, the blackening or melanosis
* albedo, the whitening or leucosis
* citrinitas, the yellowing or xanthosis
* rubedo, the reddening, purpling, or iosis The origin of these four phases can be traced at least as far back as the first century. Zosimus of Panopolis wrote that it was known to Mary the Jewess. After the 15th century, many writers tended to compress citrinitas into rubedo and consider only three stages. Other color stages are sometimes mentioned, most notably the cauda pavonis (peacock's tail) in which an array of colors appear. The magnum opus had a variety of alchemical symbols attached to it. Birds like the raven, swan, and phoenix could be used to represent the progression through the colors. Similar color changes could be seen in the laboratory, where for example, the blackness of rotting, burnt, or fermenting matter would be associated with nigredo.