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Darth Maul, later simply Maul, is a fictional character in the Star Wars franchise. A powerful Zabrak Sith Lord and Darth Sidious' first apprentice, he first appeared in Star Wars: Episode I – The Phantom Menace (1999), portrayed by Ray Park and voiced by Peter Serafinowicz. Despite his apparent death at the hands of Obi-Wan Kenobi at the end of the film, the 2008 Star Wars: The Clone Wars animated television series would reveal that Maul had actually survived his injuries, and he made further appearances in the 2014 Star Wars Rebels series and the 2018 film Solo: A Star Wars Story, all voiced by Sam Witwer, with Park physically reprising the role in the latter film.

Whiteknights Park, or the Whiteknights Campus of the University of Reading, is the principal campus of that university. The park covers the area of the manor of Earley Whiteknights, also known as Earley St Nicholas and Earley Regis. Whiteknights Park is some two miles south of the centre of the town of Reading in the English county of Berkshire. The campus is 1.3 square kilometres (321 acres) in size and includes lakes, conservation meadows and woodlands as well as being home to most of the university's academic departments and several halls of residence.

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1,2,3,4,6-Pentagalloylglucose is the pentagallic acid ester of glucose. It is a gallotannin and the precursor of ellagitannins. Pentagalloyl glucose can precipitate proteins, including human salivary α-amylase.

Chandraprakash Dwivedi is an Indian film director and script writer, who is best known for directing the 1991 television epic Chanakya in which he also played the title role of the political strategist Chanakya and an inspiration for millions. His other major work is the 2003 film Pinjar, a tragic love story set amidst the Hindu-Muslim tensions during the Partition of India, based on Amrita Pritam's novel of the same name. He has also directed the 1996 television series Mrityunjay which is based on the life of Karna, a major character from the epic Mahabharata, and he won a Screen Videocon Best Director award for the same.

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Tyrone William Griffin Jr. (born April 13, 1982), known professionally as Ty Dolla Sign (stylized as Ty Dolla $ign or Ty$), is an American singer, songwriter, rapper and record producer. He first gained major recognition in 2010 for his guest feature on YG's "Toot It and Boot It", which he had co-written and produced for Def Jam Recordings. In the summer of 2013, he signed a record deal with Wiz Khalifa's Taylor Gang Records. In November 2015, he released his debut studio album, Free TC, which peaked at number 14 on the Billboard 200. Ty Dolla Sign is known for his songs "Paranoid", "Or Nah", and "Blasé;" as well as his writing contributions to "Loyal" by Chris Brown, "Post to Be" by Omarion featuring Brown and Jhené Aiko, and "FourFiveSeconds" by Rihanna, as well his various features on singles such as "Work from Home" by Fifth Harmony, "Hot Girl Summer" by Megan Thee Stallion, also featuring Nicki Minaj, and "Psycho" by Post Malone, which was his first track as a lead artist or featured artist to hit number one on the Billboard Hot 100. Aside from his solo music career, Ty Dolla Sign is also a member of production team D.R.U.G.S., alongside Chordz 3D, Buddah Shampoo, Nate 3D, James Koo, Fuego, HbarzDidIt and DJ Dahi.

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Neurodegenerative diseases are a heterogeneous group of complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. Their underlying causes are extremely variable and complicated by various genetic and/or environmental factors. These diseases cause progressive deterioration of the neuron resulting in decreased signal transduction and in some cases even neuronal death. Peripheral nervous system (PNS) diseases may be further categorized by the type of nerve cell (motor, sensory, or both) affected by the disorder. Effective treatment of these diseases is often prevented by lack of understanding of the underlying molecular and genetic pathology. Epigenetic therapy is being investigated as a method of correcting the expression levels of misregulated genes in neurodegenerative diseases. Neurodengenerative diseases of motor neurons can cause degeneration of motor neurons involved in voluntary muscle control such as muscle contraction and relaxation. This article will cover the epigenetics and treatment of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). See the Motor Neuron Fact Sheet for details regarding other motor neuron diseases.Neurodegenerative diseases of the central nervous system can affect the brain and/or spinal cord. This article will cover the epigenetics and treatment of Alzheimer’s disease (AD), Huntington’s disease (HD), and Parkinson’s disease (PD). These diseases are characterized by chronic and progressive neuronal dysfunction, sometimes leading to behavioral abnormalities (as with PD), and, ultimately, neuronal death, resulting in dementia. Neurodegenerative diseases of sensory neurons can cause degeneration of sensory neurons involved in transmitting sensory information such as hearing and seeing. The main group of sensory neuron diseases are hereditary sensory and autonomic neuropathies (HSAN) such as HSAN I, HSAN II, and Charcot-Marie-Tooth Type 2B (CMT2B). Though some sensory neuron diseases are recognized as neurodegenerative, epigenetic factors have not yet been clarified in the molecular pathology.

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Roberto Rodriguez Aguirre is a Mexican Luchador, or professional wrestler. He works for Consejo Mundial de Lucha Libre (CMLL) in their Mini-Estrella division under the name Bracito de Oro (Spanish for "Little Golden Arm"). Aguirre's real name was not a matter of public record until he was unmasked by Pequeño Black Warrior on April 30, 2010. This is often the case with masked wrestlers in Mexico where their private lives are kept a secret from the wrestling fans and they are only forced to reveal their real name when unmasked. Working in the Mini division does not necessarily mean that Bracito de Oro has dwarfism as several short wrestlers work in the "Mini" division, which is what separates the Mexican Mini-Estrella from traditional Midget wrestling as practiced in the United States and ot

Melissa Suzanne George (born 6 August 1976) is an Australian-American actress and entrepreneur. A former national rollerskating champion and model, George began her acting career playing Angel Parrish on the Australian soap opera Home and Away (1993–96). After moving to the United States, George made her big-screen debut in 1998 in the neo-noir/science fiction film Dark City. She later appeared in Steven Soderbergh's The Limey (1999), David Lynch's Mulholland Drive (2001), Sugar & Spice (2001), and Down with Love (2003).

News of the World – the name alludes to the newspaper – is the sixth studio album by the British rock band Queen, released on 28 October 1977 by EMI Records in the United Kingdom and by Elektra Records in the United States. News of the World was the band's second album to be recorded at Sarm West and Wessex Sound Studios, London, and engineered by Mike Stone, and was co-produced by the band and Stone. In 1977, punk rock acts, most notably the Sex Pistols, sparked massive backlash against progressive rock artists such as Queen, to which the band responded by simplifying their symphonic rock sound and gearing towards a more spontaneous hard rock sound. The album subsequently went 4× platinum in the United States, reaching number 3 on the US Billboard 200, number 4 on the UK Albums Chart and achieving high certifications around the world. It has sold over 10 million copies and remains one of the band's best-selling studio albums to date. Its lead single, "We Are the Champions"/"We Will Rock You", reached number two on the UK Singles Chart and number four on the Billboard Hot 100. Critical reaction to News of the World was initially mixed, with many reviewers commenting on the band's change in musical style. However, it has since come to be regarded as one of Queen's greatest albums, while "We Are the Champions" and "We Will Rock You" have since become rock anthems.

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"Bill" is a song heard in Act II of Kern and Hammerstein's classic 1927 musical Show Boat. The song was written by Kern and P.G. Wodehouse for their 1917 musical Oh, Lady! Lady!! for Vivienne Segal to perform, but withdrawn because it was considered too melancholy for that show. However, when Kern and Hammerstein were at work on the serious and somewhat tragic Show Boat, they decided that the song would be perfect for a nightclub scene in the show. Hammerstein revised Wodehouse's original lyrics somewhat (though he would always give full credit to Wodehouse for the song and take none for himself), and the song was given to real-life nightclub singer Helen Morgan, who portrayed the mulatto Julie in Show Boat, to sing. The song is rendered only once in the show and is highly emotional, with the singer supposedly on the verge of tears. It is sung in an audition scene in Act II. At the Trocadero, a local Chicago night club, Julie LaVerne, the former leading lady of the show boat, is the featured singer. Julie, who is of mixed blood, has been permanently abandoned by her white husband, Steve Baker, years after the two were forced to leave the show boat because of their interracial (and therefore illegal) marriage. Despondent, Julie has taken to drink and is quickly becoming an alcoholic. At the urging of Jim Green, the nightclub manager, Julie rehearses the song "Bill", which is a woman's confession of deep love for a less-than-perfect man named Bill, and it is clear that the emotion that Julie puts into the song comes from the fact that she is really thinking about her husband as she sings. "Bill" became one of Helen Morgan's signature songs, and onstage she sang it in her trademark style sitting atop a piano. Although the song is heard only once in Show Boat and never reprised, it became one of the musical's most famous. On film, Helen Morgan sang "Bill" both in the prologue to the 1929 part-talkie film version of Show Boat and in the classic 1936 film version. Lena Horne was filmed singing it for the Jerome Kern biopic Till the Clouds Roll By, but the scene was eventually cut, and Ava Gardner, using the dubbed-in voice of Annette Warren, sang it in the 1951 Technicolor remake of Show Boat. Gardner's own voice can be heard on the soundtrack record. Shirley Bassey recorded the song for the 1959 Studio Cast Album of "Show Boat". The song was a regular part of Dorothy Lamour's repertoire. Lamour frequently sang it on radio and in concert and recorded it in 1958.

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The 2020 NASCAR Cup Series is the 72nd season for NASCAR professional stock car racing in the United States and the 49th season for the modern era Cup Series. The season began at Daytona International Speedway with the Busch Clash, the Bluegreen Vacations Duel qualifying races, and the 62nd running of the Daytona 500. The regular season is scheduled to end with the Coke Zero Sugar 400 at Daytona on August 29. The NASCAR playoffs is scheduled to end with the race at Phoenix Raceway on November 8.

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Muthaiga is an affluent neighborhood in the city of Nairobi, the capital of Kenya. In 2019, media reports indicated that it was the most affluent and most expensive neighborhood in the entire country.

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Israel Kaʻanoʻi Kamakawiwoʻole (Hawaiian: pronounced [kəˌmɐkəˌvivoˈʔole]; Hawaiian for '"the fearless eye, the bold face"'; May 20, 1959 – June 26, 1997), also called Bruddah Iz or IZ, was a Native Hawaiian singer-lyricist, musician, and Hawaiian sovereignty activist. He achieved commercial success outside Hawaii when his album Facing Future was released in 1993. His medley of "Somewhere Over the Rainbow/What a Wonderful World" was released on his albums Ka ʻAnoʻi and Facing Future. It was subsequently featured in several films, television programs, and television commercials. Along with his ukulele playing and incorporation of other genres, such as jazz and reggae, Kamakawiwoʻole remains influential in Hawaiian music.

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1,2,3,4,6-Penta-O-galloyl-beta-(D)-glucose

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Methodism has historically followed the Protestant tradition of referring to sanctified members of the universal church as saints. However, as a title, Saint is usually used to refer to biblical people, Christian leaders, and martyrs of the faith. While most Methodist churches place little emphasis on the veneration of Saints, they often admire, honor, and remember the saints of Christendom. John Wesley, the founder of Methodism, believed that there was much to learn from studying renowned saints, but he discouraged the 'worship' of them. He expressed concern about the Church of England's focus on saints' days and said that "most of the holy days were at present answering no valuable end." As such, Methodism does not have any system whereby people are canonised.

Arta (Greek: Άρτα) is a city in northwestern Greece, capital of the regional unit of Arta, which is part of Epirus region. The city was known in ancient times as Ambracia (Ancient Greek: Ἀμβρακία). Arta is known for the medieval bridge over the Arachthos River. Arta is also known for its ancient sites from the era of Pyrrhus of Epirus and its well-preserved 13th-century castle. Arta's Byzantine history is reflected in its many Byzantine churches; perhaps the best known is the Panagia Paregoretissa (Mother of God the Consoling), built about 1290 by Despot Nikephoros I Komnenos Doukas. The city is the seat of the Technological Educational Institute of Epirus.

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News of the World – the name alludes to the newspaper – is the sixth studio album by the British rock band Queen, released on 28 October 1977 by EMI Records in the United Kingdom and by Elektra Records in the United States. News of the World was the band's second album to be recorded at Sarm West and Wessex Sound Studios, London, and engineered by Mike Stone, and was co-produced by the band and Stone.

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David Amerson (born December 8, 1991) is an American football cornerback who is currently a free agent. He was drafted by the Washington Redskins in the second round of the 2013 NFL Draft. He has also played for the Oakland Raiders and Arizona Cardinals. He played college football at North Carolina State University.

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The 2005 Atlantic hurricane season was the most active Atlantic hurricane season in recorded history, shattering numerous records, with 31 tropical or subtropical cyclones recorded. The United States National Hurricane Center named 27 storms, exhausting the annual pre-designated list and resulting in the usage of six Greek letter names. A record 15 storms attained hurricane status, with maximum sustained winds of at least 74 mph (119 km/h); of those, a record seven became major hurricanes, which are a Category 3 or higher on the Saffir-Simpson scale. Ahead and during the season, various groups predicted, but failed to anticipate, the high amount of activity.

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Jonathan Clay "JJ" Redick (born June 24, 1984) is an American professional basketball player for the New Orleans Pelicans of the National Basketball Association (NBA). He was selected 11th overall by the Orlando Magic in the 2006 NBA draft. He played college basketball for the Duke Blue Devils. In addition to his basketball career, Redick is a podcaster, and hosts a basketball and entertainment podcast for The Ringer.

The 2005 Atlantic hurricane season was the most active Atlantic hurricane season in recorded history, shattering numerous records, with 31 tropical or subtropical cyclones recorded. The United States National Hurricane Center named 27 storms, exhausting the annual pre-designated list and resulting in the usage of six Greek letter names. A record 15 storms attained hurricane status, with maximum sustained winds of at least 74 mph (119 km/h); of those, a record seven became major hurricanes, which are a Category 3 or higher on the Saffir-Simpson scale. Ahead and during the season, various groups predicted, but failed to anticipate, the high amount of activity. Four of the season's storms became a Category 5 hurricane, the highest ranking on the scale. Emily in July reached peak intensity in the Caribbean Sea, later weakening and striking Mexico twice. In August, Katrina reached peak winds in the Gulf of Mexico but weakened by the time it struck the U.S. states of Louisiana and Mississippi. The most devastating effects of the season were felt on the Gulf Coast of the United States, where Katrina's storm surge crippled New Orleans, Louisiana, for weeks and devastated the Mississippi coastline. Katrina became the costliest U.S. hurricane, leaving $125 billion in damage and 1,833 deaths. Rita followed in September, reaching peak intensity in the Gulf of Mexico before weakening and hitting near the border of Texas and Louisiana. The season's strongest hurricane, Wilma, became the most intense Atlantic hurricane on record, as measured by barometric pressure. Lasting for ten days in October, Wilma moved over Cozumel, the Yucatán peninsula, and Florida, causing $19 billion in damage and 48 deaths. The season's impact was widespread and catastrophic. Its storms caused an estimated 3,912 deaths and approximately $171.7 billion in damage. It was the costliest season on record at the time, until its record was surpassed 12 years later. It also produced the second-highest accumulated cyclone energy (ACE) in the Atlantic basin, surpassed only by the 1933 season. The season officially began on June 1, 2005, and the first storm – Arlene – developed on June 8. Hurricane Dennis in July inflicted heavy damage to Cuba. Hurricane Stan in October was part of a broader weather system that killed 1,668 people and caused $3.96 billion in damage to eastern Mexico and Central America, with Guatemala hit the hardest. The final storm – Zeta – formed in late December and lasted until January 6, 2006.

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Sheridan Smith, OBE (born 25 June 1981) is an English actress and singer. Smith came to prominence after playing a variety of characters on sitcoms such as The Royle Family (1999–2000), Two Pints of Lager and a Packet of Crisps (2001–2009), Gavin & Stacey (2008–2010), and Benidorm (2009). She played the role of Joey Ross on the drama series Jonathan Creek (2009–2013) and went on to receive acclaim for starring in a succession of television dramas, such as Mrs Biggs (2012), Cilla (2014), The C Word (2015), Black Work (2015), and The Moorside (2017). Her feature film credits include Tower Block (2012), Quartet (2012), and The Huntsman: Winter's War (2016).

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E.ON UK is a British energy company and part of the global energy firm E.ON (which is headquartered in Essen, Germany and has around 43,000 employees worldwide). It is the second largest electricity and gas supplier in the UK and one of the Big Six energy suppliers. It was founded in 1989 as Powergen, and was listed on the London Stock Exchange and was once a constituent of the FTSE 100 Index. It has been a subsidiary of E.ON since 1 July 2002.

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[(2S,3R,4S,5R,6R)-2,3,5-Tris[(3,4,5-trihydroxybenzoyl)oxy]-6-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxan-4-yl] 3,4,5-trihydroxybenzoate

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Violet Bent Backwards Over the Grass is the upcoming debut book by American singer and songwriter Lana Del Rey. A poetry collection featuring "13 longer poems" and several short pieces, the collection will be Del Rey's first published work and will be independently released sometime in 2020. Del Rey has said on several occasions that she hopes to release the book for $1 (USD) as she finds her thoughts "priceless." In December 2019, Del Rey announced that an accompanying spoken word album will be released in January 2020 in anticipation of the book release. Half of the proceeds of the album will be used to benefit organizations dedicated to Native American land conservancy and rights protection for indigenous people in the United States. Following a delay due to personal problems, the album was supposed to be released in February through Interscope/Polydor, though the album was not published in February.

Manganese is a chemical element with the symbol Mn and atomic number 25. It is found as a free element in nature; it is often found in minerals in combination with iron. Manganese is a transition metal with a multifaceted array of industrial alloy uses, particularly in stainless steels. Historically, manganese is named for pyrolusite and other black minerals from the region of Magnesia in Greece, which also gave its name to magnesium and the iron ore magnetite. By the mid-18th century, Swedish-German chemist Carl Wilhelm Scheele had used pyrolusite to produce chlorine. Scheele and others were aware that pyrolusite (now known to be manganese dioxide) contained a new element, but they were unable to isolate it. Johan Gottlieb Gahn was the first to isolate an impure sample of manganese metal in 1774, which he did by reducing the dioxide with carbon. Manganese phosphating is used for rust and corrosion prevention on steel. Ionized manganese is used industrially as pigments of various colors, which depend on the oxidation state of the ions. The permanganates of alkali and alkaline earth metals are powerful oxidizers. Manganese dioxide is used as the cathode (electron acceptor) material in zinc-carbon and alkaline batteries. In biology, manganese(II) ions function as cofactors for a large variety of enzymes with many functions. Manganese enzymes are particularly essential in detoxification of superoxide free radicals in organisms that must deal with elemental oxygen. Manganese also functions in the oxygen-evolving complex of photosynthetic plants. While the element is a required trace mineral for all known living organisms, it also acts as a neurotoxin in larger amounts. Especially through inhalation, it can cause manganism, a condition in mammals leading to neurological damage that is sometimes irreversible.
Manganese

Dechrid Sathian Muaythai Gym (Thai: เดชฤทธิ์ เสถียรมวยไทยยิม) is a Thai Muay Thai kickboxer from the Khon Kaen province in Thailand. He is a former WPMF World 147lbs. Champion and interim WPMF World 160lbs. Champion.

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Manganese is a chemical element with the symbol Mn and atomic number 25. It is found as a free element in nature; it is often found in minerals in combination with iron. Manganese is a transition metal with a multifaceted array of industrial alloy uses, particularly in stainless steels.

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Pinakamamahal (International title: Beloved) is a 2006 Philippine television drama romance series broadcast by GMA Network. It stars Oyo Boy Sotto and Marian Rivera. It premiered on August 14, 2006 replacing Agawin Mo Man Ang Lahat. The series concluded on November 3, 2006 with a total of 60 episodes. It was replaced by Makita Ka Lang Muli in its timeslot.

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4 O'Clock Club is a British children's television series, which premiered on 13 January 2012 on CBBC and BBC HD. A second series began airing on 4 January 2013, and the third series premiered on 20 December 2013. Series 4 began airing on 29 January 2015. A fifth series was commissioned, and was filmed between June 2015 and August 2015, and began airing on 25 February 2016. A sixth series began airing on 2 March 2017, with it ending on 18 May 2017. A seventh series was commissioned and filmed in 2017, with it airing between January and April 2018. An eighth series began on 19 December 2018 with a Christmas special. On 29 December 2019 through to 5 January 2020, 3 episode Specials aired on CBBC and BBC iPlayer titled 'Flashbacks' which saw past and present cast members react to their favourite and funniest moments from the show. The Specials were filmed as part of a celebration of the show hitting it's 100th episode milestone in Series 8. Series 9 began airing on 4 February 2020.

Saints in Methodism

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Darth Maul, later simply Maul, is a fictional character in the Star Wars franchise. A powerful Zabrak Sith Lord and Darth Sidious' first apprentice, he first appeared in Star Wars: Episode I – The Phantom Menace (1999), portrayed by Ray Park and voiced by Peter Serafinowicz. Despite his apparent death at the hands of Obi-Wan Kenobi at the end of the film, the 2008 Star Wars: The Clone Wars animated television series would reveal that Maul had actually survived his injuries, and he made further appearances in the 2014 Star Wars Rebels series and the 2018 film Solo: A Star Wars Story, all voiced by Sam Witwer, with Park physically reprising the role in the latter film. The Clone Wars explores Maul's backstory, revealing that he was once a member of a group of Zabrak warriors on Dathomir called the Nightbrothers, who was abducted as a child by Sidious. Following his defeat at Kenobi's hands, Maul is driven to insanity, but is rescued by his brother Savage Opress twelve years later. After being provided with a pair of robotic legs by the Nighsisters, led by Maul's mother Talzin, he seeks revenge against Kenobi, in the process recruiting several crime syndicates to his cause to form the Shadow Collective and taking over Mandalore. He successfully exacts revenge on Kenobi, only to be defeated and captured by his former master, who saw him as a rival. Maul later escapes and manages to rebuild his criminal empire, now wishing to exact revenge on Sidious after he killed Maul's brother and mother. Near the end of the Clone Wars, he learns that Sidious seeks to make Anakin Skywalker his new apprentice, and engineers a conflict on Mandalore to lure out and kill Skywalker. However, Ahsoka Tano is sent to deal with him instead, and he unsuccessfully tries to convince her to join forces and defeat Sidious. Maul is defeated and captured by Ahsoka, though she frees him when Sidious executes Order 66, causing Ahsoka's clone troopers to turn on her, and he aids her escape by creating a distraction, before escaping himself. During the Galactic Empire era, Maul, having abandoned his Sith persona, leads the Crimson Dawn crime syndicate, until being left stranded on the Sith world of Malachor for years. He escapes after meeting Jedi Padawan Ezra Bridger, whom he attempted to turn to the dark side, and later forces him to assist in locating the long-absent Obi-Wan Kenobi. Upon tracking him down to Tatooine, he confronts Kenobi and fights him one final time. Maul is fatally injured and dies in Kenobi's arms, finally letting go of his hatred for him, as he realizes that Kenobi is looking after the boy he believes to be the Chosen One and would one day destroy the Sith, avenging all those who had suffered because of them, including Maul. Since the release of The Phantom Menace, Maul has become a become a widely recognized character in popular culture, mostly because of his unique facial tattoos and horns, and his double-bladed lightsaber. Aside from the films and television series, he has appeared in various canon and non-canon Star Wars media over the years, such as books, comics, and video games.

Melissa Suzanne George (born 6 August 1976) is an Australian-American actress and entrepreneur. A former national rollerskating champion and model, George began her acting career playing Angel Parrish on the Australian soap opera Home and Away (1993–96). After moving to the United States, George made her big-screen debut in 1998 in the neo-noir/science fiction film Dark City. She later appeared in Steven Soderbergh's The Limey (1999), David Lynch's Mulholland Drive (2001), Sugar & Spice (2001), and Down with Love (2003). In 2005, George transitioned into leading roles when she played Kathy Lutz in the remake of The Amityville Horror. She followed this with a succession of films in the thriller and horror genres, such as Derailed (2005), Turistas (2006), WΔZ (2007), 30 Days of Night (2007), Triangle (2009), A Lonely Place to Die (2011), and Felony (2013). On television, George has had recurring roles on Alias (2003–04), Grey's Anatomy (2008–09) and The Good Wife (2013–14), and a leading role on the NBC medical drama Heartbeat (2016). She received a Golden Globe nomination for her portrayal of Laura Hill on HBO's In Treatment (2008). She also starred in the Australian miniseries The Slap (2011), for which she received a Logie Award, and the BBC spy series Hunted (2012). In 2015, she appeared in the American adaptation of The Slap, playing the same character, Rosie, that she played in the previous version. She currently stars as Diane Hagerty on Hulu's The First (2018).

Friedreich's ataxia (FRDA or FA) is an autosomal recessive genetic disease that causes difficulty walking, a loss of sensation in the arms and legs and impaired speech that worsens over time. Symptoms can start between 5 and 15 years of age. Many develop hypertrophic cardiomyopathy and will require a mobility aid such as a cane, walker or wheelchair in their teens. As the disease progresses, people lose their sight and hearing. Other complications include scoliosis and diabetes mellitus. The condition is caused by mutations in the FXN gene on chromosome 9. The FXN gene makes a protein called frataxin. In FRDA, the patient produces less frataxin. Degeneration of nerve tissue in the spinal cord causes the ataxia; particularly affected are the sensory neurons essential for directing muscle movement of the arms and legs through connections with the cerebellum. The spinal cord becomes thinner and nerve cells lose some myelin sheath. No effective treatment exists, but there are several therapies in trials. FRDA shortens life expectancy due to heart disease and some people can live into their sixties or older. FRDA affects 1 in 50,000 people in the United States and is the most common inherited ataxia. Rates are highest in people of Western European descent. The condition is named after the German physician Nikolaus Friedreich, who first described it in the 1860s.

Neurodegenerative diseases are a heterogeneous group of complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. Their underlying causes are extremely variable and complicated by various genetic and/or environmental factors. These diseases cause progressive deterioration of the neuron resulting in decreased signal transduction and in some cases even neuronal death. Peripheral nervous system (PNS) diseases may be further categorized by the type of nerve cell (motor, sensory, or both) affected by the disorder. Effective treatment of these diseases is often prevented by lack of understanding of the underlying molecular and genetic pathology. Epigenetic therapy is being investigated as a method of correcting the expression l

Terrence G. Berg

José Mallorquí y Figuerola (b. 12 February 1913 in Barcelona - d. 7 November 1972 in Madrid), was a prolific Spanish writer under over 30 pseudonyms of hundreds of novellas by various popular genres. As J. Mallorquí he is internationally known for his 192 books' series El Coyote. Several of his works have been adapted for cinema. He was the father of the also writers and .

4 O'Clock Club is a British children's television series, which premiered on 13 January 2012 on CBBC and BBC HD. A second series began airing on 4 January 2013, and the third series premiered on 20 December 2013. Series 4 began airing on 29 January 2015. A fifth series was commissioned, and was filmed between June 2015 and August 2015, and began airing on 25 February 2016.

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Tyrone William Griffin Jr. (born April 13, 1982), known professionally as Ty Dolla Sign (stylized as Ty Dolla $ign or Ty$), is an American singer, songwriter, rapper and record producer. He first gained major recognition in 2010 for his guest feature on YG's "Toot It and Boot It", which he had co-written and produced for Def Jam Recordings. In the summer of 2013, he signed a record deal with Wiz Khalifa's Taylor Gang Records. In November 2015, he released his debut studio album, Free TC, which peaked at number 14 on the Billboard 200.

Shiosai
The Sound Of Waves

A promenade dance, commonly called a prom, or formal/semi-formal in Australian English is a dance party of high school students. It may be offered in semi-formal black tie or informal suit for boys, with dresses for girls. This event is typically held near the end of the senior year (the last year of high school). Proms figure greatly in popular culture and are major events among high school students. There may be individual senior (12th grade) and junior (11th grade) proms or they may be combined. At a prom, a "prom king" and a "prom queen" may be revealed. These are honorary titles awarded to students elected in a school-wide vote prior to the prom. Other students may be honored with inclusion in a prom court. The selection method for a prom court is similar to that of homecoming queen/princess, king, and court. Inclusion in a prom court may be a reflection of popularity of those students elected and their level of participation in school activities, such as clubs or sports.The "prom queen" and "prom king" may be given crowns to wear. Members of the prom court may be given sashes to wear and photographed together. Similar events, which may be locally inspired by debutante balls, take place in many other parts of the world. In Canada, the terms "formal" and "Grad" are often used, while in Australia and New Zealand, the terms school formal and ball are most commonly used for occasions equivalent to the American prom, and the event is usually held for students in Year 12, although the bestowing of the regal titles does not occur. Many schools hold a formal graduation ball for finishing students at the end of the year in place of or as well as a formal. In Ireland a debutante ball or debs may also be held. In Poland, high schools organize a "studniówka". The term "prom" is becoming more common in the United Kingdom and Canada because of the influence of American films and television shows.

Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM] There are two splice isoforms of RGS9 with quite different properties and patterns of expression. RGS9-1 is mainly found in the eye and is involved in regulation of phototransduction in rod and cone cells of the retina, while RGS9-2 is found in the brain, and regulates dopamine and opioid signaling in the basal ganglia. RGS9-2 is of particular interest as the most important RGS protein involved in terminating signalling by the mu opioid receptor (although RGS4 and RGS17 are also involved), and is thought to be important in the development of tolerance to opioid drugs. RGS9-deficient mice exhibit some motor and cognitive difficulties however, so inhibition of this protein is likely to cause similar side effects. RGS9 is differentially regulated by Guanine nucleotide-binding protein subunit beta-5 (GNB5) via the DEP domain and DEP helical-extension domain in protein stability and membrane anchor association.

News of the World (album)

The Baralong incidents were two alleged British war crimes during the First World War in August and September 1915, involving the Royal Navy Q-ship HMS Baralong and two German U-boats. Baralong sank U-27, which had been preparing to sink a nearby merchant ship, the Nicosian. About a dozen of the crewmen managed to escape from the sinking submarine, and Lieutenant Godfrey Herbert, commanding officer of Baralong, ordered the surviving sailors to be summarily executed after they boarded the Nicosian. All the survivors of U-27's sinking, including several who had reached the Nicosian, were shot by Baralong's crew. Later, Baralong sank U-41 in an incident which has also been described as a war crime.

2005 Atlantic hurricane season

Dejrit Poptheeratham

Kyuka Lilymjok was born in Bafai-Kanai, Niɡeria, on 24th September, 1965. He is a Niɡerian fictional writer and professor of law at Ahmadu Bello University (ABU), Zaria, Nigeria.

Miami Vice is an American crime drama television series created by Anthony Yerkovich and executive produced by Michael Mann for NBC. The series starred Don Johnson as James "Sonny" Crockett and Philip Michael Thomas as Ricardo "Rico" Tubbs, two Metro-Dade Police Department detectives working undercover in Miami. The series ran for five seasons on NBC from September 16, 1984 to January 25, 1990. The USA Network began airing reruns in 1988, and broadcast an originally unaired episode during its syndication run of the series on January 25, 1990.

At sufficiently high flux levels, various bands of electromagnetic radiation have been found to cause deleterious health effects in people. Electromagnetic radiation can be classified into two types: ionizing radiation and non-ionizing radiation, based on the capability of a single photon with more than 10 eV energy to ionize oxygen or break chemical bonds. Extreme ultraviolet and higher frequencies, such as X-rays or gamma rays are ionizing, and these pose their own special hazards: see radiation and radiation poisoning. The last quarter of the twentieth century saw a dramatic increase in the number of devices emitting non-ionizing radiation in all segments of society, which resulted in an elevation of health concerns by researchers and clinicians, and an associated interest in government

Kyuka Lilymjok

Carlos Gutiérrez Estefa (born 5 February 1999) is a Mexican footballer who currently plays as a midfielder for Atlético San Luis on loan from Pumas UNAM.

article

Heinrich Hoffman

Methodism has historically followed the Protestant tradition of referring to sanctified members of the universal church as saints. However, as a title, Saint is usually used to refer to biblical people, Christian leaders, and martyrs of the faith. While most Methodist churches place little emphasis on the veneration of Saints, they often admire, honor, and remember the saints of Christendom.

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families. It functions both as a hormone and a neurotransmitter, and plays several important roles in the brain and body. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter—a chemical released by neurons (nerve cells) to send signals to other nerve cells. The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior. The anticipation of most types of rewards increases the leve

Candidates for speedy deletion as implausible redirects

CONELRAD (Control of Electromagnetic Radiation) was a method of emergency broadcasting to the public of the United States in the event of enemy attack during the Cold War. It was intended to allow continuous broadcast of civil defense information to the public using radio stations, while rapidly switching the transmitter stations to make the broadcasts unsuitable for Soviet bombers that might attempt to home in on the signals (as was done during World War II, when German radio stations, based in or near cities, were used as beacons by pilots of bombers). U.S. President Harry S. Truman established CONELRAD in 1951. After the development of intercontinental ballistic missiles reduced the likelihood of a bomber attack, CONELRAD was replaced by the Emergency Broadcast System (EBS) on August 5, 1963, which was later replaced by the Emergency Alert System (EAS) on January 1, 1997; all have been administered by the Federal Communications Commission (FCC). Unlike the EBS and EAS, CONELRAD was never intended to be used for local civil emergencies such as severe weather.

Epigenetics of neurodegenerative diseases

Articles needing additional references from March 2010

Twist is a 2003 Canadian drama film directed by Jacob Tierney and starring Nick Stahl and Joshua Close. It is a retelling of Charles Dickens' classic 1838 novel Oliver Twist.

J. Mallorquí

Live Magic is a live album by British rock band Queen. It was recorded at various live shows during The Magic Tour and was released on 1 December 1986. However, it was not released in the United States until August 1996. It received strong criticism from fans, due to the heavy editing of many songs. For example, the opera section was removed from "Bohemian Rhapsody", the second verse and chorus were removed from "Tie Your Mother Down", and "Is This the World We Created...?", "We Will Rock You" and "We Are the Champions" were reduced to one verse and chorus. In July 2004, Q magazine listed Live Magic as one of the top five disappointing live albums from usually great acts. Most of the performances were recorded at Knebworth Park on 9 August 1986, which marks the band's final ever concert with its original line-up.

E.ON UK is a British energy company and part of the global energy firm E.ON (which is headquartered in Essen, Germany and has around 43,000 employees worldwide). It is the second largest electricity and gas supplier in the UK and one of the Big Six energy suppliers. It was founded in 1989 as Powergen, and was listed on the London Stock Exchange and was once a constituent of the FTSE 100 Index. It has been a subsidiary of E.ON since 1 July 2002. E.ON, was formerly a vertically integrated utility company with interests in electrical generation, electricity distribution in the Midlands region, and in the electricity and gas supply markets. It took a pioneering role in the development of large scale renewables including the construction and operation of the UK's first offshore wind farm at Blyth in Northumberland. It became one of the first in the world, and the first major UK energy company, to significantly alter its structure by spinning off its fossil generation business so it could focus on energy supply, grid development and renewables.

Wikipedia articles with ORCID identifiers

Roberto Rodriguez Aguirre is a Mexican Luchador, or professional wrestler. He works for Consejo Mundial de Lucha Libre (CMLL) in their Mini-Estrella division under the name Bracito de Oro (Spanish for "Little Golden Arm"). Aguirre's real name was not a matter of public record until he was unmasked by Pequeño Black Warrior on April 30, 2010. This is often the case with masked wrestlers in Mexico where their private lives are kept a secret from the wrestling fans and they are only forced to reveal their real name when unmasked. Working in the Mini division does not necessarily mean that Bracito de Oro has dwarfism as several short wrestlers work in the "Mini" division, which is what separates the Mexican Mini-Estrella from traditional Midget wrestling as practiced in the United States and other places. Bracito de Oro is a smaller version of professional wrestler Brazo de Oro.

Violet Bent Backwards Over the Grass is the upcoming debut book by American singer and songwriter Lana Del Rey. A poetry collection featuring "13 longer poems" and several short pieces, the collection will be Del Rey's first published work and will be independently released sometime in 2020. Del Rey has said on several occasions that she hopes to release the book for $1 (USD) as she finds her thoughts "priceless."

Female roller skaters

Propionic acid

Live Magic is a live album by British rock band Queen. It was recorded at various live shows during The Magic Tour and was released on 1 December 1986. However, it was not released in the United States until August 1996. It received strong criticism from fans, due to the heavy editing of many songs. For example, the opera section was removed from "Bohemian Rhapsody", the second verse and chorus were removed from "Tie Your Mother Down", and "Is This the World We Created...?", "We Will Rock You" and "We Are the Champions" were reduced to one verse and chorus. In July 2004, Q magazine listed Live Magic as one of the top five disappointing live albums from usually great acts.

Israel Kaʻanoʻi Kamakawiwoʻole (Hawaiian: pronounced [kəˌmɐkəˌvivoˈʔole]; Hawaiian for '"the fearless eye, the bold face"'; May 20, 1959 – June 26, 1997), also called Bruddah Iz or IZ, was a Native Hawaiian singer-lyricist, musician, and Hawaiian sovereignty activist. He achieved commercial success outside Hawaii when his album Facing Future was released in 1993. His medley of "Somewhere Over the Rainbow/What a Wonderful World" was released on his albums Ka ʻAnoʻi and Facing Future. It was subsequently featured in several films, television programs, and television commercials.

Electromagnetic radiation and health

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families. It functions both as a hormone and a neurotransmitter, and plays several important roles in the brain and body. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter—a chemical released by neurons (nerve cells) to send signals to other nerve cells. The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior. The anticipation of most types of rewards increases the level of dopamine in the brain, and many addictive drugs increase dopamine release or block its reuptake into neurons following release. Other brain dopamine pathways are involved in motor control and in controlling the release of various hormones. These pathways and cell groups form a dopamine system which is neuromodulatory. In popular culture and media, dopamine is usually seen as the main chemical of pleasure, but the current opinion in pharmacology is that dopamine instead confers motivational salience; in other words, dopamine signals the perceived motivational prominence (i.e., the desirability or aversiveness) of an outcome, which in turn propels the organism's behavior toward or away from achieving that outcome. Outside the central nervous system, dopamine functions primarily as a local paracrine messenger. In blood vessels, it inhibits norepinephrine release and acts as a vasodilator (at normal concentrations); in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it. Several important diseases of the nervous system are associated with dysfunctions of the dopamine system, and some of the key medications used to treat them work by altering the effects of dopamine. Parkinson's disease, a degenerative condition causing tremor and motor impairment, is caused by a loss of dopamine-secreting neurons in an area of the midbrain called the substantia nigra. Its metabolic precursor L-DOPA can be manufactured; Levodopa, a pure form of L-DOPA, is the most widely used treatment for Parkinson's. There is evidence that schizophrenia involves altered levels of dopamine activity, and most antipsychotic drugs used to treat this are dopamine antagonists which reduce dopamine activity. Similar dopamine antagonist drugs are also some of the most effective anti-nausea agents. Restless legs syndrome and attention deficit hyperactivity disorder (ADHD) are associated with decreased dopamine activity. Dopaminergic stimulants can be addictive in high doses, but some are used at lower doses to treat ADHD. Dopamine itself is available as a manufactured medication for intravenous injection: although it cannot reach the brain from the bloodstream, its peripheral effects make it useful in the treatment of heart failure or shock, especially in newborn babies.

At sufficiently high flux levels, various bands of electromagnetic radiation have been found to cause deleterious health effects in people. Electromagnetic radiation can be classified into two types: ionizing radiation and non-ionizing radiation, based on the capability of a single photon with more than 10 eV energy to ionize oxygen or break chemical bonds. Extreme ultraviolet and higher frequencies, such as X-rays or gamma rays are ionizing, and these pose their own special hazards: see radiation and radiation poisoning. The last quarter of the twentieth century saw a dramatic increase in the number of devices emitting non-ionizing radiation in all segments of society, which resulted in an elevation of health concerns by researchers and clinicians, and an associated interest in government regulation for safety purposes. By far the most common health hazard of radiation is sunburn, which causes over one million new skin cancers annually in United States.

Terrence George Berg (born August 1959) is a United States District Judge of the United States District Court for the Eastern District of Michigan.

June 5 is the 156th day of the year (157th in leap years) in the Gregorian calendar. 209 days remain until the end of the year.

The Arch of Malborghetto is an Ancient Roman quadrifrons arch (that is, an arch with four pylons) located nineteen kilometres north of Rome on the via Flaminia. Today, because of reuse over the centuries, it is part of a mass of construction which appears to be a Medieval structure at first sight. Nevertheless, the core of the structure is datable to the first half of the fourth century. The original marble coating has been completely lost.

David Amerson

Propionic acid (, from the Greek words protos, meaning "first", and pion, meaning "fat"; also known as propanoic acid) is a naturally occurring carboxylic acid with chemical formula CH3CH2CO2H. It is a liquid with a pungent and unpleasant smell somewhat resembling body odor. The anion CH3CH2CO2− as well as the salts and esters of propionic acid are known as propionates or propanoates.

Jonathan Clay "JJ" Redick (born June 24, 1984) is an American professional basketball player for the New Orleans Pelicans of the National Basketball Association (NBA). He was selected 11th overall by the Orlando Magic in the 2006 NBA draft. He played college basketball for the Duke Blue Devils. In college, Redick was known for his good three-point and free throw shooting. He set ACC records during his career for most points and most career ACC tournament points, though his ACC career points record was subsequently broken at UNC in 2009. Redick is currently the all-time leading scorer for Duke. He also set several other Duke records, including most points in a single season. Redick's jersey was retired by Duke on February 4, 2007. After being drafted by the Magic, he played for seven seasons in Orlando, followed by a short spell with the Milwaukee Bucks, then four seasons with the Los Angeles Clippers. In 2017, he signed a one-year contract with the Philadelphia 76ers, and re-signed with them on a one-year deal the following year. In 2019, Redick signed a two-year deal with the New Orleans Pelicans. In addition to his basketball career, Redick is a podcaster, and hosts a basketball and entertainment podcast for The Ringer.

CONELRAD (Control of Electromagnetic Radiation) was a method of emergency broadcasting to the public of the United States in the event of enemy attack during the Cold War. It was intended to allow continuous broadcast of civil defense information to the public using radio stations, while rapidly switching the transmitter stations to make the broadcasts unsuitable for Soviet bombers that might attempt to home in on the signals (as was done during World War II, when German radio stations, based in or near cities, were used as beacons by pilots of bombers).

1,2,3,4,6-Pentakis-O-galloyl-beta-(D)-glucose

Miami Vice is an American crime drama television series created by Anthony Yerkovich and executive produced by Michael Mann for NBC. The series starred Don Johnson as James "Sonny" Crockett and Philip Michael Thomas as Ricardo "Rico" Tubbs, two Metro-Dade Police Department detectives working undercover in Miami. The series ran for five seasons on NBC from September 16, 1984 to January 25, 1990. The USA Network began airing reruns in 1988, and broadcast an originally unaired episode during its syndication run of the series on January 25, 1990. Unlike standard police procedurals, the show drew heavily upon 1980s New Wave culture and music. The show became noted for its integration of music and visual effects. It has been called one of the "Top 50 TV Shows". People magazine stated that Miami Vice was the "first show to look really new and different since color TV was invented". Michael Mann directed a film adaptation of the series, which was released July 28, 2006.
Miami Vice

A promenade dance, commonly called a prom, or formal/semi-formal in Australian English is a dance party of high school students. It may be offered in semi-formal black tie or informal suit for boys, with dresses for girls. This event is typically held near the end of the senior year (the last year of high school). Proms figure greatly in popular culture and are major events among high school students. There may be individual senior (12th grade) and junior (11th grade) proms or they may be combined.

The 2020 NASCAR Cup Series is the 72nd season for NASCAR professional stock car racing in the United States and the 49th season for the modern era Cup Series. The season began at Daytona International Speedway with the Busch Clash, the Bluegreen Vacations Duel qualifying races, and the 62nd running of the Daytona 500. The regular season is scheduled to end with the Coke Zero Sugar 400 at Daytona on August 29. The NASCAR playoffs is scheduled to end with the race at Phoenix Raceway on November 8. This is the first season under NASCAR's new tiered sponsorship model after rejecting Monster Energy's offer to extend its title sponsorship. On December 5, 2019, NASCAR announced Busch Beer, Coca-Cola, GEICO, and Xfinity as the Premier Partners of the NASCAR Cup Series, replacing the sole title sponsor of Monster Energy. This season was scheduled to be the final year for the Gen-6 car, with the Next Gen car (formerly the Gen-7 car) debuting in 2021. However, when the coronavirus pandemic postponed all NASCAR racing (and therefore, testing) until the month of May, the sanctioning body announced that the debut of the car would be pushed back a year to 2022. It was announced that 2020 will be the last full-time season for seven-time series champion Jimmie Johnson as well as for part-timer Brendan Gaughan. When the season was put on hold due to the coronavirus, drivers from all NASCAR series, including most Cup Series drivers, participated in the inaugural eNASCAR iRacing Pro Invitational Series.

Arta

Sheridan Smith, OBE (born 25 June 1981) is an English actress and singer. Smith came to prominence after playing a variety of characters on sitcoms such as The Royle Family (1999–2000), Two Pints of Lager and a Packet of Crisps (2001–2009), Gavin & Stacey (2008–2010), and Benidorm (2009). She played the role of Joey Ross on the drama series Jonathan Creek (2009–2013) and went on to receive acclaim for starring in a succession of television dramas, such as Mrs Biggs (2012), Cilla (2014), The C Word (2015), Black Work (2015), and The Moorside (2017). Her feature film credits include Tower Block (2012), Quartet (2012), and The Huntsman: Winter's War (2016). Smith has performed in the West End musicals Little Shop of Horrors (2007), Legally Blonde (2010), Funny Girl (2016), and Joseph and the Amazing Technicolour Dreamcoat (2019). She released her debut album, Sheridan, in 2017. Her second album, A Northern Soul, was released in 2018. In late 2006, Smith started voicing Lucie Miller for Doctor Who, as part of the BBC7 Big Finish audio range, alongside Paul McGann's Eighth Doctor, in the story Blood of the Daleks. Sheridan's last audio adventure for Big Finish was To The Death, in 2011, in which Lucie died. Smith is the recipient of two Olivier Awards, a BAFTA, a National Television Award and a BPG Award, as well as two International Emmy Award nominations. She was appointed Officer of the Order of the British Empire (OBE) in the 2015 New Year Honours for services to drama.

"Bill" is a song heard in Act II of Kern and Hammerstein's classic 1927 musical Show Boat. The song was written by Kern and P.G. Wodehouse for their 1917 musical Oh, Lady! Lady!! for Vivienne Segal to perform, but withdrawn because it was considered too melancholy for that show. However, when Kern and Hammerstein were at work on the serious and somewhat tragic Show Boat, they decided that the song would be perfect for a nightclub scene in the show. Hammerstein revised Wodehouse's original lyrics somewhat (though he would always give full credit to Wodehouse for the song and take none for himself), and the song was given to real-life nightclub singer Helen Morgan, who portrayed the mulatto Julie in Show Boat, to sing.

Actor/director/writer/historian

The Sound of Waves

Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM] RGS9 is differentially regulated by Guanine nucleotide-binding protein subunit beta-5 (GNB5) via the DEP domain and DEP helical-extension domain in protein stability and membrane anchor association.

1,2,3,4,6-Penta-O-galloyl-β-(D)-glucose

Friedreich Ataxia

List of 4 O'Clock Club episodes

Friedreich's ataxia (FRDA or FA) is an autosomal recessive genetic disease that causes difficulty walking, a loss of sensation in the arms and legs and impaired speech that worsens over time. Symptoms can start between 5 and 15 years of age. Many develop hypertrophic cardiomyopathy and will require a mobility aid such as a cane, walker or wheelchair in their teens. As the disease progresses, people lose their sight and hearing. Other complications include scoliosis and diabetes mellitus.

beta-Penta-O-galloyl-glucose