LYCE (software bundle)

LX chipset

LYNX Light Rail

LYAO

--4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid

KOR

LYCOS Europe

LY-367,265 is a drug developed by Eli Lilly, which acts as both a potent and selective antagonist at the serotonin 5-HT2A receptor, and also a selective serotonin reuptake inhibitor (SSRI). It has antidepressant effects in animal studies, reduces glutamate signalling in the brain and increases the analgesic effects of morphine.

LY-255582 is a phenylpiperidine non-selective opioid antagonist. It has been shown to reduce ethanol consumption in experiments carried out on rats. It has also been shown to reduce food and water consumption in rats.

LY-404,187 (or LY404187) is an ampakine (or "AMPA receptor potentiator") developed by Eli Lilly and Company. It is a member of the biarylpropylsulfonamide class of ampakines.LY-404,187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD. These effects appear to be mediated through multiple mechanisms of action secondary to AMPA receptor potentiation, with a prominent effect seen in research being increased levels of BDNF in the brain. It may therefore be continued on to human trials, although Eli Lilly has developed a whole family of biarylpropylsulfonamide derivatives and it is unclear at this stage which compound is most likely to be selected for further development.

GDAJGLDMCDMPIR-UHFFFAOYSA-N

LYPJ

LYRIC 145

LYN (gene)

LY-310762 is a drug which acts as a potent and selective antagonist for the 5-HT1D serotonin receptor, with reasonable selectivity over the closely related 5-HT1B subtype.

LYPLAL1

LXR (disambiguation)

LYCEE PAUL VALERY

oral

LYLAS (group)

LYRA (Lyman Alpha Radiometer) is the solar UV radiometer on board Proba-2, a European Space Agency technology demonstration satellite that was launched on November 2, 2009.LYRA has been designed and manufactured by a Belgian-Swiss-German consortium (ROB-SIDC, PMOD/WRC, IMOMEC, CSL, MPS and BISA) with additional international collaborations (Japan, USA, Russia, and France).

LYNX Deodorant

LX Cycling Team

LYPLAL1 (gene)

LYNX Blue Line

yes

LY6G6E

LYPD3

changed

LX Cycling Team is a South Korean UCI Continental road cycling team founded in 2016.

LX legislature of the mexican congress

LYR Electric Units

LYM Inequality

ALMACYDZFBMGOR-UHFFFAOYSA-N

VLZBRVJVCCNPRJ-KPHUOKFYSA-N

LXM Pro Tour, or LXM Pro, is a California-based professional men's field lacrosse showcase that features many of the sport's most accomplished players. LXM Pro Tour was founded by former college lacrosse and Major League Lacrosse players, notably former Johns Hopkins star Kyle HarrisonThe tour has demonstrated a pattern of being able to draw some of the top collegiate and professional players away from the more established MLL.

LYAR (gene)

8a-decahydroisoquinoline-3-carboxylic acid

LYNX1 (gene)

LX National QSL Bureau

LXI Legislature of the Mexican Congress

LXOH

LYAO is the second live album from stand-up comedian Arj Barker. Warner Bros. Records/Degenerate Records comic Arj Barker released his second comedy album, LYAO, on Tuesday, January 26, 2010, after the Comedy Central special premiered Saturday, Jan. 23. LYAO is also available on CD/DVD and standalone DVD.

LX (disambiguation)

LYRA (Lyman Alpha Radiometer) is the solar UV radiometer on board Proba-2, a European Space Agency technology demonstration satellite that was launched on November 2, 2009.LYRA has been designed and manufactured by a Belgian-Swiss-German consortium (ROB-SIDC, PMOD/WRC, IMOMEC, CSL, MPS and BISA) with additional international collaborations (Japan, USA, Russia, and France). Jean-François Hochedez (ROB) is Principal Investigator, Yves Stockman (CSL) is Project Manager, and Werner Schmutz (PMOD) is Lead co-Investigator.LYRA will monitor the Solar irradiance in four UV passbands. They have been chosen for their relevance to solar physics, aeronomy and Space Weather:the 115-125 nm Lyman-α channel,the 200-220 nm Herzberg continuum channel,the Aluminium filter channel (17-50 nm) including He II at 30.4 nm, andthe Zirconium filter channel (1-20 nm).The Radiometric calibration of the instrument is traceable to Synchrotron source standards, Physikalisch-Technische Bundesanstalt (PTB) and National Institute of Standards and Technology (NIST). Its stability will be monitored by onboard calibration light sources (light-emitting diodes), which allow distinguishing between potential degradations of the detectors and filters. Additionally, a redundancy strategy contributes to the accuracy and the stability of the measurements. LYRA will benefit from wide bandgap detectors based on diamond: it will be the first space assessment of a pioneering UV detectors program. Diamond sensors make the instruments radiation-hard and solar-blind: their high bandgap energy makes them quasi-insensitive to visible light (see also references in Marchywka Effect). The SWAP extreme ultraviolet (EUV) imaging telescope will operate next to LYRA on Proba-2. Together, they will establish a high performance solar monitor for operational space weather nowcasting and research. LYRA demonstrates technologies important for future missions such as the ESA Solar Orbiter mission.

LYS-16

LY-320,135 is a drug used in scientific research which acts as a selective antagonist of the cannabinoid receptor CB1. It was developed by Eli Lilly and Company in the 1990s.LY-320,135 displays fairly good selectivity, with a binding affinity for CB1 around 70x stronger than for CB2, but both its potency and selectivity are modest compared to newer agents, and at higher doses it also binds to a range of non-cannabinoid receptors. However LY-320,135 is still fairly widely used in research, particularly for elucidating the mechanisms by which many CB1 antagonists act as inverse agonists at higher doses.

LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic and anxiolytic effects.

LXXX

LYR electric units (Manchester)

C1=CC=CCC2=CC=CC=C2

LYNX

LY-293284 is a research chemical developed by the pharmaceutical company Eli Lilly and used for scientific studies. It acts as a potent and selective 5-HT1A receptor full agonist. It was derived through structural simplification of the ergoline based psychedelic LSD, but is far more selective for 5-HT1A with over 1000x selectivity over other serotonin receptor subtypes and other targets. It has anxiogenic effects in animal studies.
CKYZLYQSDNLGPT-HNNXBMFYSA-N

LYMEC

LYI

[2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol

LY-2459989 is a silent antagonist of the κ-opioid receptor (KOR) that has been developed by Eli Lilly as a radiotracer of the aforementioned receptor, labeled either with carbon-11 or fluorine-18. It possesses high affinity for the KOR (Ki = 0.18 nM) and is highly selective for it over the μ-opioid receptor (Ki = 7.68 nM) and the δ-opioid receptor (Ki = 91.3 nM) (over 43-fold selectivity for the KOR over the other opioid receptors).

AIALBPYHYGYYRB-UHFFFAOYSA-N

LYMB is an object-oriented development environment aimed at developing applications that require combining graphics-based user interfaces, visualization, and rapid prototyping.

LYH

The LXI Legislature of the Congress of Mexico met from September 1, 2009, to August 31, 2012. Members of the upper house of the Congress were selected in the elections of July 2006 while members of the lower house of the Congress were selected in the elections of July 2009.

LYBT

LYPD1

LY-503,430 is an ampakine drug developed by Eli Lilly.LY-503,430 produces both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP and also increasing levels of the neurotrophic factor BDNF in the brain, particularly in the substantia nigra, hippocampus and striatum.

LYNX (body spray)

LYNX Body Spray

Lancashire & Yorkshire Railway

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.

LYPLA1 (gene)

(6aR,9R,10aR)-N-((1S,2R)-2-hydroxycyclopentyl)-4-isopropyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

LX Legislature

LYTV

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation.

LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and was useful in early studies of this receptor family, although it has largely been replaced by newer drugs such as LY-341,495.

Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene.This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins. Transgenic mice without Lynx2 expression have increased anxiety-related behaviors.

LY96

LXTV is the brand name of a lifestyle and entertainment programming production unit owned by NBC Universal that creates "hyper-local" content. Started in 2006 by former MTV executives Morgan Hertzan and Joseph Varet as a privately owned broadband TV network and website, LXTV was acquired in January 2008 by NBC Owned Television Stations (formerly NBC Local Media), a division of NBCUniversal. LXTV was formed after the company – originally focused exclusively on web-based content – was approached by NYC TV head Arick Wierson about forming a joint production partnership. NYC TV, which later went on to forge a content partnership with NBC´s local New York station, WNBC, brought LXTV into the NBC deal, thus giving the former web-only company access to the top local grossing local TV station in the U.S. After repeated attempts to acquire the production arm of NYC TV (due to NYC TV's public-owned status) NBC opted instead to buy LXTV, so it could create similar hyper-local fare for itself.Some of LXTV’s programs include 1st Look, Open House, Open House NYC and George to the Rescue, which presents lifestyle programming to a young affluent audience.LXTV also created and launched New York Live (formerly LX New York), the live, daily lifestyle show on WNBC, broadcast from Studio 3K in 30 Rockefeller Plaza and live from the streets in and around New York.

N,N-dimethyl-5-[(4-biphenyl)methyl]tetrazole-1-carboxamide

LYNS

CHN

The LX National QSL Bureau provides a service by volunteers to exchange amateur radio QSL cards between Luxembourgish amateur radio operators and amateur radio operators from the world. The LX National QSL Bureau was founded in July 2014 by the Association des Radioamateurs du Kayldall (ADRAD) and by the Luxembourg Amateur Radio Union (LARU).The LX National QSL Bureau was closed in July 2015 on an initiative of the ADRAD Kayldall.

LYPD3 (gene)

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.

DWLOVDOPFJPWNE-HKUYNNGSSA-N

LYNX (deodorant)

The Lancashire and Yorkshire Railway (LYR) built suburban electric stock for lines in Liverpool and Manchester. The line between Liverpool to Southport began using electric multiple units (EMUs) on 22 March 1904, using a third rail 625 V DC. Additional trains were later built for this route, and in 1913 incompatible stock for the route to Ormskirk. Lightweight units were built to run on the Liverpool Overhead Railway.The Southport units was replaced in the early 1940s; after regular through services onto the LOR were withdrawn the lightweight units were used on local Crossens services until 1945; the Ormskirk units were withdrawn in 1964.In 1913 an experimental 3.5 kV DC overhead line system operated between Bury and Holcombe Brook in the Manchester area, and 1.2 kV DC with a side-contact third rail between Manchester Victoria and Bury. Electric services started in 1916, the Bury to Holcombe Brook route being converted in 1918. The cars were replaced in 1959/60.

LY-215,840 is an ergoline derivative drug developed by Eli Lilly, which acts as a potent and selective antagonist at the serotonin 5-HT2 and 5-HT7 receptors. It has anti-hypertensive and muscle relaxant effects in animal studies.

LX tape

LYNX (Deodorant)

LYC (disambiguation)

C1[C@@H]CO

LYS Airport

N,N-dimethyl-5-[methyl]tetrazole-1-carboxamide

LYSMD3

LYNX Silver Line

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.

LYR

AVDUGNCTZRCAHH-MDASVERJSA-N

The LX Legislature (60th) of the Congress of Mexico met from September 1, 2006, to September 1, 2009. All members of both the lower and upper houses of Congress were elected in the elections of July 2006.

N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide

LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals, and blocks the effects of PCP and DOI, which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia in animals.There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.

LXR

Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.LY75 has also recently been designated CD205 (cluster of differentiation 205). CD205 is also known as DEC-205.

N-[2-propyl]propane-2-sulfonamide

LYSMD3 (gene)

LXV

LY6E

LYRA (disambiguation)

Group XV phospholipase A2 is an enzyme that in humans is encoded by the PLA2G15 gene.Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.

N-- N-pyrid- 3-ylmethylamine

LYC

(-2-Amino-2-[-2-carboxycycloprop-1-yl]-3-propanoic acid)

N-(4-(2-methoxyphenoxy)phenyl)- N-(2,2,2-trifluoroethylsulfonyl)pyrid- 3-ylmethylamine

c3ccccc3CC2CCNCCN1CCc4c1cccc4

LX 498

LYNDA DAY GEORGE

LYSD

LYNN LEWIS

LX–IIBS Cycling Team

LY-2183240 is a drug which acts both as a potent inhibitor of the reuptake of the endocannabinoid anandamide and as an inhibitor of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY-2183240 has been shown to produce both analgesic and anxiolytic effects in animal models. While LY-2183240 is a potent inhibitor of FAAH, it has relatively poor selectivity and also inhibits several other enzyme side targets. Consequently, it was never developed for clinical use, though it remains widely used in research, and has also been sold as a designer drug.

LYLE

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. Ly6E is associated with drug resistance and tumor immune escape in breast cancer. Further research is required to validate Ly6E for translation research. [1]

LYS-16 was an early microcomputer based on the IMP-16 making it one of the first 16 bit microcomputers. It was designed and made by members of the Lysator academic computer club at Linköping University, SwedenIt was introduced in April 1975 and the first computers were delivered in December the same year. Two batches were made by Lysator before the production was handed over to ATEW in Flen who continued to produce it until May 1978. About 1000 units were made. For display it used an ordinary TV and for storage a tape recorder. A rudimentary operating system was available.

[H][C@]12[C@]CN[C@H]C1

C1[C@]N

LX Platform

LYPFF

LYIT

LY-487,379 is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR2. It is used to study the structure and function of this receptor subtype, and LY-487,379 along with various other mGluR2/3 agonists and positive modulators are being investigated as possible antipsychotic and anxiolytic drugs.

LXSS

LY-272,015 is a beta-carboline derivative drug developed by Eli Lilly, which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor. It has anti-hypertensive effects in animal models, and is also used in research into the other functions of the 5-HT2B receptor.

LX 3597

none

LysM and putative peptidoglycan-binding domain-containing protein 3 is a protein that in humans is encoded by the LYSMD3 gene.

LYSJ

LY-235,959 is a competitive antagonist at the NMDA receptor. It has analgesic and neuroprotective effects and causes hypothermia in animal models, as well as reducing the development of tolerance to morphine and altering the reinforcing effects of cocaine.

(LY-404,187; N-2-[4-phenyl]propyl-2-propanesulfonamide)

LYR (disambiguation)

LY-2940094, also known as BTRX-246040, is a potent and selective nociceptin receptor antagonist which is under investigation by Eli Lilly for the treatment of major depressive disorder (MDD) and alcohol dependence. It has demonstrated proof-of-concept clinical efficacy for depression. As of 2015, it is in phase II clinical trials for both of the aforementioned indications. However, it has more recently been reported that development for these indications has been discontinued and that the drug is now under development instead for the treatment of neurological disorders.

LY75

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.

LYNX deodorant

LYNX Body spray

LYL1 (gene)

LXRUN

LYNX (Body spray)

3,3-Dimethyl-1-(2-[4-(4-fluorobenzoyl)piperidin-1-yl]-1-ethyl)-1,3-dihydro-2H-indol-2-one

FC1=CC=C2C=C1

LYRA

Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene.

LYNX1

RYNSGDFWBJWWSZ-UHFFFAOYSA-N

Investigational New Drug

LYME and LYCE are solution stacks composed entirely of free and open-source software to build high-availability heavy duty dynamic web pages. The stacks are composed of:Linux, the operating system;Yaws, the web server;Mnesia or CouchDB, the database;Erlang, the functional programming language.The LYME and LYCE bundles can be and are combined with many other free and open-source software packages such as e.g.

LYBE

LYNX bodyspray

LYTO

LYNX (Bodyspray)

LYT10

LYPB

(LY-272,015; 1-[methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole)

LYME and LYCE are solution stacks composed entirely of free and open-source software to build high-availability heavy duty dynamic web pages. The stacks are composed of:Linux, the operating system;Yaws, the web server;Mnesia or CouchDB, the database;Erlang, the functional programming language.The LYME and LYCE bundles can be and are combined with many other free and open-source software packages such as e.g. netsniff-ng for security testing and hardening, Snort, an intrusion detection (IDS) and intrusion prevention system (IPS), RRDtool for diagrams, or Nagios, Collectd, or Cacti, for monitoring.

None

LYNX body spray

LXMusic

LYS-16 was an early microcomputer based on the IMP-16 making it one of the first 16 bit microcomputers. It was designed and made by members of the Lysator academic computer club at Linköping University, SwedenIt was introduced in April 1975 and the first computers were delivered in December the same year. Two batches were made by Lysator before the production was handed over to ATEW in Flen who continued to produce it until May 1978. About 1000 units were made.

CN1[C@]CC4=CNC5=CC=CC2=C54

LYG

LXR-alpha

LXM Pro Tour logo

LYR electric units

CCSNCCcccc2-cccc1CNC

LYLAB

LYL

LYM inequality

LYBV

LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, but is still widely used in research itself.

LYKV

LY6 refers to a family of proteins found in leukocytes. They were discovered in the 1970s and are used as surface markers for leukocyte identification.

LYNX Red Line

LYNK

Investigational

LYA

LXLE

LY5

(−)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid

LYL1

LY-2940094, also known as BTRX-246040, is a potent and selective nociceptin receptor antagonist which is under investigation by Eli Lilly for the treatment of major depressive disorder (MDD) and alcohol dependence. It has demonstrated proof-of-concept clinical efficacy for depression. As of 2015, it is in phase II clinical trials for both of the aforementioned indications.

LYSF

LXRα

LYK5

LXN

September 2009 to August 2012
LXI Legislature

LXXXVIII

LYTR

The Lacrosse Network https://www.youtube.com/user/TheLacrosseNetwork

Not FDA-approved

STIRHCNEGQQBOY-QEYWKRMJSA-N

LYMPHTOFU polynomial

DRGHCUTTXWIERB-NRFANRHFSA-N

LXTV

CCCN[C@H]1CC2=CNC3=C2CC1

LYR Railmotor

LXTV is the brand name of a lifestyle and entertainment programming production unit owned by NBC Universal that creates "hyper-local" content. Started in 2006 by former MTV executives Morgan Hertzan and Joseph Varet as a privately owned broadband TV network and website, LXTV was acquired in January 2008 by NBC Owned Television Stations (formerly NBC Local Media), a division of NBCUniversal.

LYB

LYPR

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene. LY9 has also recently been designated CD229 (cluster of differentiation 229).

NKQHBJNRBKHUQR-UHFFFAOYSA-N

LYMB

LYPO

LXM Pro Tour

3-{(3R,4R)-1-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-3,4-dimethyl-4-piperidinyl}phenol

LXXVTS10 b

LYNYRD SKYNYRD

LY2181308 is an antisense oligonucleotide that complementarily binds to survivin mRNA and inhibits its expression in tumor tissue.It being investigated for a number of different cancers.It is targeted at survivin which prevents cells dying.

The Lancashire and Yorkshire Railway (LYR) built suburban electric stock for lines in Liverpool and Manchester. The line between Liverpool to Southport began using electric multiple units (EMUs) on 22 March 1904, using a third rail 625 V DC. Additional trains were later built for this route, and in 1913 incompatible stock for the route to Ormskirk.

LYN

LYT-10

(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)pentan-1,5-dioic acid

LYNX Rapid Transit Services

LYS

LY-2459989 is a silent antagonist of the κ-opioid receptor (KOR) that has been developed by Eli Lilly as a radiotracer of the aforementioned receptor, labeled either with carbon-11 or fluorine-18. It possesses high affinity for the KOR (Ki = 0.18 nM) and is highly selective for it over the μ-opioid receptor (Ki = 7.68 nM) and the δ-opioid receptor (Ki = 91.3 nM) (over 43-fold selectivity for the KOR over the other opioid receptors). LY-2459989 is a fluorine-containing analogue and follow-up compound of LY-2795050, the first-ever KOR-selective antagonist radiotracer. Relative to LY-2795050, LY-2459989 displays 4-fold higher affinity for the KOR and similar selectivity and also possesses greatly improved central nervous system permeation (brain levels were found to be 6-fold higher than those of LY-2795050). The drug appears to possess a short duration of action, with only 25% remaining in serum at 30 minutes post-injection in rhesus monkeys, making it an ideal agent for application in biomedical imaging, for instance in positron emission tomography (PET).Earlier analogues of LY-2459989 besides LY-2795050 with similar actions and potential uses have also been described.

LY-404,187 (or LY404187) is an ampakine (or "AMPA receptor potentiator") developed by Eli Lilly and Company. It is a member of the biarylpropylsulfonamide class of ampakines.LY-404,187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD.

LY-341,495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3).It is used in scientific research in several different areas, showing antidepressant effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the analgesic effects of μ-opioid agonists, as well as modulating dopamine receptor function.The 1-fluorocyclopropane analog has a superior pharmacokinetic profile and similar mGluR2/3 affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further.

LYAR

LYNX (bodyspray)

LYTB

variable: 2, 3, 4 or 5 cars

YASVRZWVUGJELU-MDASVERJSA-N

(4R)-6-acetyl-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz[c,d]indole

LXQT

LY-320,135 is a drug used in scientific research which acts as a selective antagonist of the cannabinoid receptor CB1. It was developed by Eli Lilly and Company in the 1990s.LY-320,135 displays fairly good selectivity, with a binding affinity for CB1 around 70x stronger than for CB2, but both its potency and selectivity are modest compared to newer agents, and at higher doses it also binds to a range of non-cannabinoid receptors.

c3ncccc3CNc2cccOc1ccccc1OC

c4cccc3c4nc2c3CCNC2Ccccc1OC

LY75 (gene)

LXXI

LYST

LYA (airport)

-N--4-isopropyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

LYNX (light rail system)

LXC

LXXIEJ 12

LYRASIS

LYCAA

LYONS, Daniel

LY-503,430 is an ampakine drug developed by Eli Lilly.LY-503,430 produces both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP and also increasing levels of the neurotrophic factor BDNF in the brain, particularly in the substantia nigra, hippocampus and striatum. It is orally active and the main application it is currently being developed for is treatment of Parkinson's Disease although it has also been proposed to be useful in the treatment of Alzheimer's Disease, depression and schizophrenia.

LXVR

LYNX Central Station

BJIPVHLRWSDKOS-UHFFFAOYSA-N

LYD

4'-{(1S)-1-fluoro-2-[(isopropylsulfonyl)amino]-1-methylethyl}-N-methylbiphenyl-4-carboxamide

LYPLA1

LXXVI Army Corps (Germany)

[2-[4-[methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol

LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic and anxiolytic effects. LY-404,039 is intended as a treatment for schizophrenia and other psychotic and anxiety disorders by modulating glutamatergic activity and reducing presynaptic release of glutamate at synapses in limbic and forebrain areas relevant to these disorders. Human studies investigating therapeutic use of LY-404,039 have focused on the prodrug LY-2140023, a methionine amide of LY-404,039 (also called pomaglumetad methionil or LY-2140023 monohydrate) since LY-404,039 exhibits low oral absorption and bioavailability in humans.Early human trials using this prodrug form of LY-404,039 gave encouraging results. However, pharmaceutical company Eli Lilly terminated further development of the compound in 2012 after it failed in phase II clinical trials. In September 2013, the results of a randomized, placebo-controlled clinical trial investigating the impact of adjunctive LY-2140023 on prominent negative symptoms in schizophrenia was published and failed to demonstrate any benefit.In 2015, Denovo Biopharma exclusively licensed LY-2140023 (the prodrug) for further development, having identified "a meaningful subset of patients who showed significantly improved outcomes".

LXRB

LYM

LYS (sailing)

LYNX Purple Line

LXR-α

LYNX West Corridor

LYO

LYNX (Body Spray)

3-Fluoro-4-[4-[[(2S)-2-pyridin-3-ylpyrrolidin-1-yl]methyl]phenoxy]benzamide

Ly6/neurotoxin 1 is a protein in humans that is encoded by the LYNX1 gene. Alternatively spliced variants encoding different isoforms have been identified.

LX 498 Crossair

LYNX Bodyspray

LXXVI Panzer Corps (Germany)

LXVII

LX Legislature of the Mexican Congress

LXXVTS10 a

LY96 (gene)

LY6E (gene)

LY-60

LYPLA3

LYSU

LYPLA3 (gene)

LYLAS (American Group)

LY-80

LYPG

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone).LYAR contains a zinc finger motif and three copies of nuclear localization signals. LYAR is mainly localized to the nucleoli. LYAR is present at high levels in early embryos and preferentially in the liver fetal thymus.

LXXII

LYPD1 (gene)

LYE

LY-2183240 is a drug which acts both as a potent inhibitor of the reuptake of the endocannabinoid anandamide and as an inhibitor of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY-2183240 has been shown to produce both analgesic and anxiolytic effects in animal models.

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LYQS

LYTE Records

LYSM

LYRtech inc.

Ly6/PLAUR domain-containing protein 3 is a protein that in humans is encoded by the LYPD3 gene.

LX executable

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR), CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family.

1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl)-1,4,5,6-tetrahydro-[1,2,5]thiadiazolo[4,3,2-ij]quinoline 2,2-dioxide

2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-(D)-alanine

LY9

LXX

1-(3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-tetrahydro-1H-β-carboline

4-[6-methoxy-2-(4-methoxyphenyl)1-benzofuran-3-carbonyl]benzonitrile

LXR-beta

(LY-503,430; -4'-[1-fluoro-1-methyl-2--ethyl]-biphenyl-4-carboxylic acid methylamide)

LYBR

LYNX Blue Line Extension

N#Cc2ccc-c1ccccc1

LYNI

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LYR Railmotors

LY6

(1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid

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LYP

Issue Were Here

Group XV phospholipase A2 is an enzyme that in humans is encoded by the PLA2G15 gene.Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene.

LYME (software bundle)

LXS

LYU

LY9 (gene)

Cc1cCN3CCC4c5cCF

Arj Barker LYAO.jpeg

LXRA

LYLAS

NCc1ccccc1